4WTD

CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH ADP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AUAAAUUU

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MN P 601

Chain	Residue
A	ASP220
A	ASP318
A	ASP319
A	MN601
P	U8
P	ADP602
P	HOH704

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site_id	AC2
Number of Residues	18
Details	binding site for residue ADP P 602

Chain	Residue
A	ILE160
A	ASP220
A	THR221
A	HIS223
A	PHE224
A	ASP225
A	SER282
A	ASN291
A	ASP318
A	MN601
P	U8
P	MN601
P	HOH704
P	HOH705
T	U2
T	A3
A	ARG48
A	ARG158

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site_id	AC3
Number of Residues	6
Details	binding site for residue MN A 601

Chain	Residue
A	ASP220
A	THR221
A	ASP318
P	MN601
P	ADP602
P	HOH705

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site_id	AC4
Number of Residues	2
Details	binding site for residue MN A 602

Chain	Residue
A	GLU237
A	HIS254

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site_id	AC5
Number of Residues	5
Details	binding site for residue CL A 603

Chain	Residue
A	GLY375
A	PRO376
A	ARG377
A	GLY378
A	ARG379

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P26663

Chain	Residue	Details
A	ASP220
A	ASP318
A	ASP319

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