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4WRY

Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase in complex with 5-fluorouracil(B), Form I

Functional Information from GO Data
ChainGOidnamespacecontents
A0004844molecular_functionuracil DNA N-glycosylase activity
A0005737cellular_componentcytoplasm
A0006281biological_processDNA repair
A0006284biological_processbase-excision repair
A0016787molecular_functionhydrolase activity
A0016799molecular_functionhydrolase activity, hydrolyzing N-glycosyl compounds
A0097510biological_processbase-excision repair, AP site formation via deaminated base removal
Functional Information from PDB Data
site_idAC1
Number of Residues12
Detailsbinding site for residue CIT A 301
ChainResidue
AGLN67
AHOH408
AHOH411
AHOH524
AALA160
AGLY169
AARG170
AASN183
ALEU195
ASER196
AHOH403
AHOH406

site_idAC2
Number of Residues9
Detailsbinding site for residue URF A 302
ChainResidue
AGLY66
AGLN67
AASP68
ATYR70
ASER80
APHE81
AASN127
AHIS191
AHOH624

site_idAC3
Number of Residues2
Detailsbinding site for residue CL A 303
ChainResidue
AARG41
AARG133

Functional Information from PROSITE/UniProt
site_idPS00130
Number of Residues10
DetailsU_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. RVLIvGQDPY
ChainResidueDetails
AARG61-TYR70

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000250
ChainResidueDetails
AASP68

226707

PDB entries from 2024-10-30

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