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4WK7

Crystal structure of human ADAMTS-4 in complex with inhibitor (compound 1, 2-(4-chlorophenoxy)-N-{[(4R)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl} acetamide)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 501
ChainResidue
AHIS361
AHIS365
AHIS371
A3PQ505

site_idAC2
Number of Residues6
Detailsbinding site for residue CA A 502
ChainResidue
AHOH686
AGLU221
AASP304
AASP311
ACYS423
AASP426

site_idAC3
Number of Residues5
Detailsbinding site for residue CA A 503
ChainResidue
AGLU221
AASP304
AASP426
AHOH691
AHOH696

site_idAC4
Number of Residues6
Detailsbinding site for residue CA A 504
ChainResidue
AASP320
ALEU321
ACYS327
ATHR329
AGLU349
AHOH699

site_idAC5
Number of Residues15
Detailsbinding site for residue 3PQ A 505
ChainResidue
ATHR329
ALEU330
AGLY331
AHIS361
AGLU362
AHIS365
AHIS371
AVAL390
AALA392
APRO393
AVAL394
AMET395
AVAL398
AZN501
AHOH685

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAAHELGHVF
ChainResidueDetails
ATHR358-PHE367

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673
ChainResidueDetails
AGLU362

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:18042673
ChainResidueDetails
AHIS361
AHIS365
AHIS371

219140

PDB entries from 2024-05-01

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