4WIG
Crystal structure of E47D mutant cytidine deaminase from Mycobacterium tuberculosis (MtCDA E47D)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004126 | molecular_function | cytidine deaminase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0043100 | biological_process | pyrimidine nucleobase salvage |
| A | 0046109 | biological_process | uridine biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| A | 0072527 | biological_process | pyrimidine-containing compound metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004126 | molecular_function | cytidine deaminase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0043100 | biological_process | pyrimidine nucleobase salvage |
| B | 0046109 | biological_process | uridine biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| B | 0072527 | biological_process | pyrimidine-containing compound metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 201 |
| Chain | Residue |
| A | CYS56 |
| A | CYS89 |
| A | CYS92 |
| A | HOH305 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 201 |
| Chain | Residue |
| B | CYS56 |
| B | CYS89 |
| B | CYS92 |
| B | HOH305 |
Functional Information from PROSITE/UniProt
| site_id | PS00903 |
| Number of Residues | 41 |
| Details | CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. CAEcaVVcalhstgggrllalacvdghgsvlm........PCgr......CrqvL |
| Chain | Residue | Details |
| A | CYS56-LEU96 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 244 |
| Details | Domain: {"description":"CMP/dCMP-type deaminase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20035876","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
