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4WG3

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1610

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004683molecular_functioncalmodulin-dependent protein kinase activity
A0005509molecular_functioncalcium ion binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0006468biological_processprotein phosphorylation
A0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0035556biological_processintracellular signal transduction
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue UWA A 601
ChainResidue
ALEU57
ALEU181
AASP195
APHE196
AHOH726
ALYS59
AVAL65
AALA78
ALYS80
AMET112
ALEU126
AGLU129
ATYR131

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGSFGEVIlCkdkitgqe..........CAVK
ChainResidueDetails
ALEU57-LYS80

site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKNGDGQLDraEL
ChainResidueDetails
AASP368-LEU380
AASP415-PHE427
AASP451-LEU463
AASP485-PHE497

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNLLL
ChainResidueDetails
AILE170-LEU182

218853

PDB entries from 2024-04-24

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