4WFO

manganese-substituted soybean lipoxygenase-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0016165	molecular_function	linoleate 13S-lipoxygenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A	0019395	biological_process	fatty acid oxidation
A	0031408	biological_process	oxylipin biosynthetic process
A	0034440	biological_process	lipid oxidation
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0102299	molecular_function	linolenate 9R-lipoxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MN A 901

Chain	Residue
A	HIS499
A	HIS504
A	HIS690
A	ASN694
A	ILE839
A	HOH1308

---

site_id	AC2
Number of Residues	8
Details	binding site for residue EDO A 902

Chain	Residue
A	VAL520
A	LEU521
A	LYS526
A	HOH1402
A	HOH1879
A	ALA145
A	ASN146
A	HIS147

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 903

Chain	Residue
A	ASP291
A	GLY295
A	GLY296
A	LYS298
A	HOH1057
A	HOH1103
A	HOH1121

---

site_id	AC4
Number of Residues	6
Details	binding site for residue EDO A 904

Chain	Residue
A	ILE412
A	ALA569
A	VAL570
A	HOH1547
A	HOH1565
A	HOH1618

---

site_id	AC5
Number of Residues	10
Details	binding site for residue EDO A 905

Chain	Residue
A	PHE346
A	LYS483
A	ALA484
A	ILE487
A	MET705
A	ASN706
A	PRO708
A	TYR734
A	HOH1331
A	HOH1355

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 906

Chain	Residue
A	ALA385
A	LEU388
A	LEU390
A	THR394
A	MET395

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 907

Chain	Residue
A	ASN190
A	GLY223
A	PRO224
A	PRO229
A	ASN230
A	THR231
A	HOH2038

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 908

Chain	Residue
A	GLN495
A	HIS499
A	LEU546
A	LEU754
A	HOH1308
A	HOH1898
A	HOH2010

---

site_id	AC9
Number of Residues	7
Details	binding site for residue EDO A 909

Chain	Residue
A	HIS147
A	THR148
A	SER774
A	ASP775
A	HOH1606
A	HOH1742
A	HOH2134

---

site_id	AD1
Number of Residues	9
Details	binding site for residue ACT A 910

Chain	Residue
A	ASP440
A	ASP607
A	SER804
A	LEU805
A	GLY807
A	ASN808
A	HOH1764
A	HOH1924
A	HOH2037

---

site_id	AD2
Number of Residues	8
Details	binding site for residue ACT A 911

Chain	Residue
A	VAL205
A	ASN230
A	TYR317
A	ARG318
A	THR319
A	HOH1002
A	HOH1148
A	HOH1182

---

site_id	AD3
Number of Residues	8
Details	binding site for residue ACT A 912

Chain	Residue
A	THR555
A	THR556
A	ALA710
A	PRO743
A	HOH1465
A	HOH1497
A	HOH1501
A	HOH2106

---

site_id	AD4
Number of Residues	11
Details	binding site for residue ACT A 913

Chain	Residue
A	GLY89
A	SER90
A	ASP389
A	LEU390
A	ASP391
A	GLY392
A	TYR393
A	HOH1004
A	HOH1105
A	HOH1252
A	HOH1261

---

site_id	AD5
Number of Residues	7
Details	binding site for residue ACT A 914

Chain	Residue
A	HIS290
A	GLN337
A	SER338
A	TRP340
A	MET341
A	HOH1049
A	HOH1193

---

site_id	AD6
Number of Residues	4
Details	binding site for residue ACT A 915

Chain	Residue
A	LYS233
A	HOH1056
A	HOH1179
A	HOH1259

---

Functional Information from PROSITE/UniProt

site_id	PS00081
Number of Residues	11
Details	LIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. LHPIyKLLtPH

Chain	Residue	Details
A	LEU521-HIS531

---

site_id	PS00711
Number of Residues	15
Details	LIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HQlmsHwLNTHAAmE

Chain	Residue	Details
A	HIS494-GLU508

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	691
Details	Domain: {"description":"Lipoxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00726","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00726","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8502991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2SBL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8502991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2SBL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---