4WFG

Human TRAAK K+ channel in a Tl+ bound conductive conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005267	molecular_function	potassium channel activity
A	0016020	cellular_component	membrane
A	0071805	biological_process	potassium ion transmembrane transport
B	0005267	molecular_function	potassium channel activity
B	0016020	cellular_component	membrane
B	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue TL A 301

Chain	Residue
A	THR129
A	THR238
A	TL307
B	THR129
B	THR238

---

site_id	AC2
Number of Residues	10
Details	binding site for residue TL A 302

Chain	Residue
A	TL303
A	TL307
B	ILE130
B	GLY131
B	VAL239
B	GLY240
A	ILE130
A	GLY131
A	VAL239
A	GLY240

---

site_id	AC3
Number of Residues	9
Details	binding site for residue TL A 303

Chain	Residue
A	GLY131
A	TYR132
A	GLY240
A	PHE241
A	TL302
B	GLY131
B	TYR132
B	GLY240
B	PHE241

---

site_id	AC4
Number of Residues	3
Details	binding site for residue TL A 304

Chain	Residue
A	CYS218
A	ASP222
A	TRP223

---

site_id	AC5
Number of Residues	4
Details	binding site for residue CA A 305

Chain	Residue
A	SER112
A	ASP115
A	SER118
A	ASP249

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA A 306

Chain	Residue
A	GLY98
A	ASP100
A	HIS111
A	HOH419
B	GLU58
B	HOH418

---

site_id	AC7
Number of Residues	10
Details	binding site for residue TL A 307

Chain	Residue
A	THR129
A	ILE130
A	THR238
A	VAL239
A	TL301
A	TL302
B	THR129
B	ILE130
B	THR238
B	VAL239

---

site_id	AC8
Number of Residues	2
Details	binding site for residue TL B 303

Chain	Residue
B	CYS218
B	TRP223

---

site_id	AC9
Number of Residues	3
Details	binding site for residue CA G 301

Chain	Residue
G	GLU10
G	LYS19
G	HOH407

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
D	TYR191-HIS197

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	46
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157

Chain	Residue	Details
A	MET27-SER29
A	GLY177-ALA198
B	MET27-SER29
B	GLY177-ALA198

---

site_id	SWS_FT_FI2
Number of Residues	198
Details	TRANSMEM: Helical => ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157

Chain	Residue	Details
A	THR30-PHE50
A	LEU144-ILE176
A	MET199-MET220
A	LEU260-VAL286
B	THR30-PHE50
B	LEU144-ILE176
B	MET199-MET220
B	LEU260-VAL286

---

site_id	SWS_FT_FI3
Number of Residues	172
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157

Chain	Residue	Details
A	ARG51-ALA113
A	ALA136-ARG143
A	GLU221-LYS225
A	ALA246-PRO259
B	ARG51-ALA113
B	ALA136-ARG143
B	GLU221-LYS225
B	ALA246-PRO259

---

site_id	SWS_FT_FI4
Number of Residues	28
Details	INTRAMEM: Helical; Name=Pore helix 1 => ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157

Chain	Residue	Details
A	TRP114-THR128
B	TRP114-THR128

---

site_id	SWS_FT_FI5
Number of Residues	22
Details	INTRAMEM: INTRAMEM => ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157

Chain	Residue	Details
A	THR129-VAL135
A	GLY240-VAL245
B	THR129-VAL135
B	GLY240-VAL245

---

site_id	SWS_FT_FI6
Number of Residues	26
Details	INTRAMEM: Helical; Name=Pore helix 2 => ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:23341632, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157

Chain	Residue	Details
A	LEU226-VAL239
B	LEU226-VAL239

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	GLN104
A	GLN108
B	GLN104
B	GLN108

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