4W9O

The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1R)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
E	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue 3JQ A 201

Chain	Residue
A	TYR57
A	ALA112
A	TYR113
A	SER118
A	PHE130
A	HOH411
A	HOH414
A	HOH419
E	3JQ201
E	HOH411
A	PHE67
A	ASP68
A	PHE77
A	GLY84
A	GLN85
A	VAL86
A	ILE87
A	TRP90

---

site_id	AC2
Number of Residues	18
Details	binding site for residue 3JQ E 201

Chain	Residue
A	3JQ201
E	TYR57
E	PHE67
E	ASP68
E	PHE77
E	GLY84
E	GLN85
E	VAL86
E	ILE87
E	TRP90
E	ALA112
E	TYR113
E	SER118
E	PHE130
E	HOH376
E	HOH387
E	HOH399
E	HOH430

---

site_id	AC3
Number of Residues	7
Details	binding site for residue ACT E 202

Chain	Residue
E	GLY13
E	ALA14
E	PRO15
E	MET48
E	ASP51
E	LYS60
E	HOH357

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site_id	AC4
Number of Residues	6
Details	binding site for residue ACT E 203

Chain	Residue
A	HIS56
A	HOH319
A	HOH325
A	HOH335
E	SER62
E	ASN63

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:28147277

Chain	Residue	Details
A	LYS28
E	LYS28

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