Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4W6Z

YEAST ALCOHOL DEHYDROGENASE I, SACCHAROMYCES CEREVISIAE FERMENTATIVE ENZYME

Replaces: 2HCY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000947	biological_process	amino acid catabolic process to alcohol via Ehrlich pathway
A	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
A	0004552	molecular_function	octanol dehydrogenase (NAD+) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0008270	molecular_function	zinc ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0019170	molecular_function	methylglyoxal reductase (NADH) activity
A	0019655	biological_process	pyruvate fermentation to ethanol
A	0042802	molecular_function	identical protein binding
A	0047655	molecular_function	allyl-alcohol dehydrogenase activity
A	0120542	molecular_function	ethanol dehydrogenase (NAD+) activity
A	1904408	molecular_function	melatonin binding
A	1990362	molecular_function	butanol dehydrogenase (NAD+) activity
B	0000947	biological_process	amino acid catabolic process to alcohol via Ehrlich pathway
B	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
B	0004552	molecular_function	octanol dehydrogenase (NAD+) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0008270	molecular_function	zinc ion binding
B	0016491	molecular_function	oxidoreductase activity
B	0019170	molecular_function	methylglyoxal reductase (NADH) activity
B	0019655	biological_process	pyruvate fermentation to ethanol
B	0042802	molecular_function	identical protein binding
B	0047655	molecular_function	allyl-alcohol dehydrogenase activity
B	0120542	molecular_function	ethanol dehydrogenase (NAD+) activity
B	1904408	molecular_function	melatonin binding
B	1990362	molecular_function	butanol dehydrogenase (NAD+) activity
C	0000947	biological_process	amino acid catabolic process to alcohol via Ehrlich pathway
C	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
C	0004552	molecular_function	octanol dehydrogenase (NAD+) activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0008270	molecular_function	zinc ion binding
C	0016491	molecular_function	oxidoreductase activity
C	0019170	molecular_function	methylglyoxal reductase (NADH) activity
C	0019655	biological_process	pyruvate fermentation to ethanol
C	0042802	molecular_function	identical protein binding
C	0047655	molecular_function	allyl-alcohol dehydrogenase activity
C	0120542	molecular_function	ethanol dehydrogenase (NAD+) activity
C	1904408	molecular_function	melatonin binding
C	1990362	molecular_function	butanol dehydrogenase (NAD+) activity
D	0000947	biological_process	amino acid catabolic process to alcohol via Ehrlich pathway
D	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
D	0004552	molecular_function	octanol dehydrogenase (NAD+) activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0008270	molecular_function	zinc ion binding
D	0016491	molecular_function	oxidoreductase activity
D	0019170	molecular_function	methylglyoxal reductase (NADH) activity
D	0019655	biological_process	pyruvate fermentation to ethanol
D	0042802	molecular_function	identical protein binding
D	0047655	molecular_function	allyl-alcohol dehydrogenase activity
D	0120542	molecular_function	ethanol dehydrogenase (NAD+) activity
D	1904408	molecular_function	melatonin binding
D	1990362	molecular_function	butanol dehydrogenase (NAD+) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ZN A 401

Chain	Residue
A	CYS43
A	THR45
A	HIS66
A	CYS153
A	8ID403
A	ETF404

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 402

Chain	Residue
A	CYS103
A	CYS111
A	CYS97
A	MET98
A	CYS100

site_id	AC3
Number of Residues	32
Details	binding site for residue 8ID A 403

Chain	Residue
A	CYS43
A	HIS44
A	THR45
A	HIS48
A	TRP54
A	CYS153
A	THR157
A	GLY177
A	ALA179
A	GLY180
A	GLY181
A	LEU182
A	ILE200
A	ASP201
A	LYS206
A	PHE221
A	VAL245
A	SER246
A	SER248
A	ALA251
A	VAL268
A	GLY269
A	MET270
A	SER293
A	TYR294
A	VAL295
A	ARG340
A	ZN401
A	ETF404
A	HOH515
A	HOH516
B	VAL284

site_id	AC4
Number of Residues	10
Details	binding site for residue ETF A 404

Chain	Residue
A	CYS43
A	THR45
A	TRP54
A	HIS66
A	TRP92
A	CYS153
A	MET270
A	TYR294
A	ZN401
A	8ID403

site_id	AC5
Number of Residues	5
Details	binding site for residue ZN B 401

Chain	Residue
B	CYS43
B	HIS66
B	GLU67
B	CYS153
B	ETF404

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 402

Chain	Residue
B	CYS97
B	CYS100
B	CYS103
B	CYS111

site_id	AC7
Number of Residues	6
Details	binding site for residue ETF B 404

Chain	Residue
B	THR45
B	HIS66
B	CYS153
B	MET270
B	VAL295
B	ZN401

site_id	AC8
Number of Residues	6
Details	binding site for residue ZN C 401

Chain	Residue
C	CYS43
C	THR45
C	HIS66
C	CYS153
C	8ID403
C	ETF404

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN C 402

Chain	Residue
C	CYS97
C	CYS100
C	CYS103
C	CYS111

site_id	AD1
Number of Residues	32
Details	binding site for residue 8ID C 403

Chain	Residue
C	GLY269
C	MET270
C	SER293
C	TYR294
C	VAL295
C	ARG340
C	ZN401
C	ETF404
C	HOH513
C	HOH514
D	VAL284
C	CYS43
C	HIS44
C	THR45
C	HIS48
C	TRP54
C	CYS153
C	THR157
C	GLY177
C	ALA179
C	GLY180
C	GLY181
C	LEU182
C	ILE200
C	ASP201
C	LYS206
C	PHE221
C	VAL245
C	SER246
C	SER248
C	ALA251
C	VAL268

site_id	AD2
Number of Residues	10
Details	binding site for residue ETF C 404

Chain	Residue
C	CYS43
C	THR45
C	TRP54
C	HIS66
C	TRP92
C	CYS153
C	MET270
C	TYR294
C	ZN401
C	8ID403

site_id	AD3
Number of Residues	5
Details	binding site for residue ZN D 401

Chain	Residue
D	CYS43
D	HIS66
D	GLU67
D	CYS153
D	ETF404

site_id	AD4
Number of Residues	5
Details	binding site for residue ZN D 402

Chain	Residue
D	CYS97
D	MET98
D	CYS100
D	CYS103
D	CYS111

site_id	AD5
Number of Residues	6
Details	binding site for residue ETF D 404

Chain	Residue
D	THR45
D	HIS66
D	CYS153
D	VAL295
D	ZN401
D	HOH526

Functional Information from PROSITE/UniProt

site_id	PS00059
Number of Residues	15
Details	ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEgAGVvvgmGenV

Chain	Residue	Details
A	GLY65-VAL79

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25157460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26743849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4W6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ENV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26743849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ENV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"description":"in the open conformation","evidences":[{"source":"PubMed","id":"25157460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26743849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4W6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ENV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"320000","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	20
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)