Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000947 | biological_process | amino acid catabolic process to alcohol via Ehrlich pathway |
A | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
A | 0004552 | molecular_function | octanol dehydrogenase (NAD+) activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005886 | cellular_component | plasma membrane |
A | 0006116 | biological_process | NADH oxidation |
A | 0008270 | molecular_function | zinc ion binding |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019170 | molecular_function | methylglyoxal reductase (NADH) activity |
A | 0019655 | biological_process | glycolytic fermentation to ethanol |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0047655 | molecular_function | allyl-alcohol dehydrogenase activity |
A | 1904408 | molecular_function | melatonin binding |
A | 1990362 | molecular_function | butanol dehydrogenase (NAD+) activity |
B | 0000947 | biological_process | amino acid catabolic process to alcohol via Ehrlich pathway |
B | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
B | 0004552 | molecular_function | octanol dehydrogenase (NAD+) activity |
B | 0005515 | molecular_function | protein binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005886 | cellular_component | plasma membrane |
B | 0006116 | biological_process | NADH oxidation |
B | 0008270 | molecular_function | zinc ion binding |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0019170 | molecular_function | methylglyoxal reductase (NADH) activity |
B | 0019655 | biological_process | glycolytic fermentation to ethanol |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0047655 | molecular_function | allyl-alcohol dehydrogenase activity |
B | 1904408 | molecular_function | melatonin binding |
B | 1990362 | molecular_function | butanol dehydrogenase (NAD+) activity |
C | 0000947 | biological_process | amino acid catabolic process to alcohol via Ehrlich pathway |
C | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
C | 0004552 | molecular_function | octanol dehydrogenase (NAD+) activity |
C | 0005515 | molecular_function | protein binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005886 | cellular_component | plasma membrane |
C | 0006116 | biological_process | NADH oxidation |
C | 0008270 | molecular_function | zinc ion binding |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0019170 | molecular_function | methylglyoxal reductase (NADH) activity |
C | 0019655 | biological_process | glycolytic fermentation to ethanol |
C | 0042802 | molecular_function | identical protein binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0047655 | molecular_function | allyl-alcohol dehydrogenase activity |
C | 1904408 | molecular_function | melatonin binding |
C | 1990362 | molecular_function | butanol dehydrogenase (NAD+) activity |
D | 0000947 | biological_process | amino acid catabolic process to alcohol via Ehrlich pathway |
D | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
D | 0004552 | molecular_function | octanol dehydrogenase (NAD+) activity |
D | 0005515 | molecular_function | protein binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005886 | cellular_component | plasma membrane |
D | 0006116 | biological_process | NADH oxidation |
D | 0008270 | molecular_function | zinc ion binding |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0019170 | molecular_function | methylglyoxal reductase (NADH) activity |
D | 0019655 | biological_process | glycolytic fermentation to ethanol |
D | 0042802 | molecular_function | identical protein binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0047655 | molecular_function | allyl-alcohol dehydrogenase activity |
D | 1904408 | molecular_function | melatonin binding |
D | 1990362 | molecular_function | butanol dehydrogenase (NAD+) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue ZN A 401 |
Chain | Residue |
A | CYS43 |
A | THR45 |
A | HIS66 |
A | CYS153 |
A | 8ID403 |
A | ETF404 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue ZN A 402 |
Chain | Residue |
A | CYS103 |
A | CYS111 |
A | CYS97 |
A | MET98 |
A | CYS100 |
site_id | AC3 |
Number of Residues | 32 |
Details | binding site for residue 8ID A 403 |
Chain | Residue |
A | CYS43 |
A | HIS44 |
A | THR45 |
A | HIS48 |
A | TRP54 |
A | CYS153 |
A | THR157 |
A | GLY177 |
A | ALA179 |
A | GLY180 |
A | GLY181 |
A | LEU182 |
A | ILE200 |
A | ASP201 |
A | LYS206 |
A | PHE221 |
A | VAL245 |
A | SER246 |
A | SER248 |
A | ALA251 |
A | VAL268 |
A | GLY269 |
A | MET270 |
A | SER293 |
A | TYR294 |
A | VAL295 |
A | ARG340 |
A | ZN401 |
A | ETF404 |
A | HOH515 |
A | HOH516 |
B | VAL284 |
site_id | AC4 |
Number of Residues | 10 |
Details | binding site for residue ETF A 404 |
Chain | Residue |
A | CYS43 |
A | THR45 |
A | TRP54 |
A | HIS66 |
A | TRP92 |
A | CYS153 |
A | MET270 |
A | TYR294 |
A | ZN401 |
A | 8ID403 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue ZN B 401 |
Chain | Residue |
B | CYS43 |
B | HIS66 |
B | GLU67 |
B | CYS153 |
B | ETF404 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue ZN B 402 |
Chain | Residue |
B | CYS97 |
B | CYS100 |
B | CYS103 |
B | CYS111 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue ETF B 404 |
Chain | Residue |
B | THR45 |
B | HIS66 |
B | CYS153 |
B | MET270 |
B | VAL295 |
B | ZN401 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue ZN C 401 |
Chain | Residue |
C | CYS43 |
C | THR45 |
C | HIS66 |
C | CYS153 |
C | 8ID403 |
C | ETF404 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue ZN C 402 |
Chain | Residue |
C | CYS97 |
C | CYS100 |
C | CYS103 |
C | CYS111 |
site_id | AD1 |
Number of Residues | 32 |
Details | binding site for residue 8ID C 403 |
Chain | Residue |
C | GLY269 |
C | MET270 |
C | SER293 |
C | TYR294 |
C | VAL295 |
C | ARG340 |
C | ZN401 |
C | ETF404 |
C | HOH513 |
C | HOH514 |
D | VAL284 |
C | CYS43 |
C | HIS44 |
C | THR45 |
C | HIS48 |
C | TRP54 |
C | CYS153 |
C | THR157 |
C | GLY177 |
C | ALA179 |
C | GLY180 |
C | GLY181 |
C | LEU182 |
C | ILE200 |
C | ASP201 |
C | LYS206 |
C | PHE221 |
C | VAL245 |
C | SER246 |
C | SER248 |
C | ALA251 |
C | VAL268 |
site_id | AD2 |
Number of Residues | 10 |
Details | binding site for residue ETF C 404 |
Chain | Residue |
C | CYS43 |
C | THR45 |
C | TRP54 |
C | HIS66 |
C | TRP92 |
C | CYS153 |
C | MET270 |
C | TYR294 |
C | ZN401 |
C | 8ID403 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue ZN D 401 |
Chain | Residue |
D | CYS43 |
D | HIS66 |
D | GLU67 |
D | CYS153 |
D | ETF404 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue ZN D 402 |
Chain | Residue |
D | CYS97 |
D | MET98 |
D | CYS100 |
D | CYS103 |
D | CYS111 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for residue ETF D 404 |
Chain | Residue |
D | THR45 |
D | HIS66 |
D | CYS153 |
D | VAL295 |
D | ZN401 |
D | HOH526 |
Functional Information from PROSITE/UniProt
site_id | PS00059 |
Number of Residues | 15 |
Details | ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEgAGVvvgmGenV |
Chain | Residue | Details |
A | GLY65-VAL79 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 28 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25157460, ECO:0000269|PubMed:26743849, ECO:0007744|PDB:4W6Z, ECO:0007744|PDB:5ENV |
Chain | Residue | Details |
A | CYS43 | |
B | CYS97 | |
B | CYS100 | |
B | CYS103 | |
B | CYS111 | |
B | CYS153 | |
C | CYS43 | |
C | HIS66 | |
C | CYS97 | |
C | CYS100 | |
C | CYS103 | |
A | HIS66 | |
C | CYS111 | |
C | CYS153 | |
D | CYS43 | |
D | HIS66 | |
D | CYS97 | |
D | CYS100 | |
D | CYS103 | |
D | CYS111 | |
D | CYS153 | |
A | CYS97 | |
A | CYS100 | |
A | CYS103 | |
A | CYS111 | |
A | CYS153 | |
B | CYS43 | |
B | HIS66 |
site_id | SWS_FT_FI2 |
Number of Residues | 56 |
Details | BINDING: BINDING => ECO:0000269|PubMed:26743849, ECO:0007744|PDB:5ENV |
Chain | Residue | Details |
A | HIS44 | |
A | VAL268 | |
A | MET270 | |
A | SER293 | |
A | VAL295 | |
A | ARG340 | |
B | HIS44 | |
B | THR45 | |
B | HIS48 | |
B | GLY180 | |
B | GLY181 | |
A | THR45 | |
B | LEU182 | |
B | ASP201 | |
B | LYS206 | |
B | PHE221 | |
B | VAL268 | |
B | MET270 | |
B | SER293 | |
B | VAL295 | |
B | ARG340 | |
C | HIS44 | |
A | HIS48 | |
C | THR45 | |
C | HIS48 | |
C | GLY180 | |
C | GLY181 | |
C | LEU182 | |
C | ASP201 | |
C | LYS206 | |
C | PHE221 | |
C | VAL268 | |
C | MET270 | |
A | GLY180 | |
C | SER293 | |
C | VAL295 | |
C | ARG340 | |
D | HIS44 | |
D | THR45 | |
D | HIS48 | |
D | GLY180 | |
D | GLY181 | |
D | LEU182 | |
D | ASP201 | |
A | GLY181 | |
D | LYS206 | |
D | PHE221 | |
D | VAL268 | |
D | MET270 | |
D | SER293 | |
D | VAL295 | |
D | ARG340 | |
A | LEU182 | |
A | ASP201 | |
A | LYS206 | |
A | PHE221 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: in the open conformation => ECO:0000269|PubMed:25157460, ECO:0000269|PubMed:26743849, ECO:0007744|PDB:4W6Z, ECO:0007744|PDB:5ENV |
Chain | Residue | Details |
A | GLU67 | |
B | GLU67 | |
C | GLU67 | |
D | GLU67 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: N-acetylserine => ECO:0000269|PubMed:320000 |
Chain | Residue | Details |
A | SER1 | |
B | SER1 | |
C | SER1 | |
D | SER1 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358 |
Chain | Residue | Details |
A | SER212 | |
B | SER212 | |
C | SER212 | |
D | SER212 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17287358 |
Chain | Residue | Details |
A | THR222 | |
B | THR222 | |
C | THR222 | |
D | THR222 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
Chain | Residue | Details |
A | SER278 | |
B | SER278 | |
C | SER278 | |
D | SER278 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:15665377, ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198 |
Chain | Residue | Details |
A | SER315 | |
B | SER315 | |
C | SER315 | |
D | SER315 |
site_id | SWS_FT_FI9 |
Number of Residues | 20 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
Chain | Residue | Details |
A | LYS225 | |
B | LYS318 | |
C | LYS225 | |
C | LYS233 | |
C | LYS286 | |
C | LYS318 | |
D | LYS225 | |
D | LYS233 | |
D | LYS286 | |
D | LYS318 | |
A | LYS233 | |
A | LYS286 | |
A | LYS318 | |
B | LYS225 | |
B | LYS233 | |
B | LYS286 |