Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4W5B

Crystal structure analysis of cruzain with Fragment 1 (N-(1H-benzimidazol-2-yl)-1,3-dimethyl-pyrazole-4-carboxamide)

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
B0006508biological_processproteolysis
B0008234molecular_functioncysteine-type peptidase activity
C0006508biological_processproteolysis
C0008234molecular_functioncysteine-type peptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue 3H5 A 301
ChainResidue
AGLN19
AHOH439
ACYS22
AGLY23
ASER25
AGLY65
AGLY66
AASP161
AHIS162
ATRP184

site_idAC2
Number of Residues10
Detailsbinding site for residue 3H5 B 301
ChainResidue
BGLN19
BCYS22
BGLY23
BSER25
BGLY65
BGLY66
BASP161
BHIS162
BGLY163
BTRP184

site_idAC3
Number of Residues11
Detailsbinding site for residue 3H5 C 301
ChainResidue
BGLN124
CGLY23
CSER25
CTRP26
CGLY66
CLEU67
CMET68
CALA138
CASP161
CGLY163
CHOH403

Functional Information from PROSITE/UniProt
site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LDHGVLLVGYN
ChainResidueDetails
ALEU160-ASN170

site_idPS00640
Number of Residues20
DetailsTHIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIiKNSWttqWGeeGYIrI
ChainResidueDetails
ATYR177-ILE196

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsACT_SITE:
ChainResidueDetails
ASER25
AHIS162
AASN182
BSER25
BHIS162
BASN182
CSER25
CHIS162
CASN182

site_idSWS_FT_FI2
Number of Residues3
DetailsSITE: Cleavage; by autolysis => ECO:0000269|PubMed:1559982
ChainResidueDetails
AGLY215
BGLY215
CGLY215

site_idSWS_FT_FI3
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN47
AASN170
BASN47
BASN170
CASN47
CASN170

226707

PDB entries from 2024-10-30

PDB statisticsPDBj update infoContact PDBjnumon