4V2R

Ironing out their differences: Dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005737	cellular_component	cytoplasm
A	0006558	biological_process	L-phenylalanine metabolic process
A	0006559	biological_process	L-phenylalanine catabolic process
A	0009698	biological_process	phenylpropanoid metabolic process
A	0009800	biological_process	cinnamic acid biosynthetic process
A	0009820	biological_process	alkaloid metabolic process
A	0009821	biological_process	alkaloid biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016841	molecular_function	ammonia-lyase activity
A	0016853	molecular_function	isomerase activity
A	0016869	molecular_function	intramolecular aminotransferase activity
A	0042617	biological_process	paclitaxel biosynthetic process
A	0045548	molecular_function	phenylalanine ammonia-lyase activity
A	0051289	biological_process	protein homotetramerization
B	0003824	molecular_function	catalytic activity
B	0005737	cellular_component	cytoplasm
B	0006558	biological_process	L-phenylalanine metabolic process
B	0006559	biological_process	L-phenylalanine catabolic process
B	0009698	biological_process	phenylpropanoid metabolic process
B	0009800	biological_process	cinnamic acid biosynthetic process
B	0009820	biological_process	alkaloid metabolic process
B	0009821	biological_process	alkaloid biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016841	molecular_function	ammonia-lyase activity
B	0016853	molecular_function	isomerase activity
B	0016869	molecular_function	intramolecular aminotransferase activity
B	0042617	biological_process	paclitaxel biosynthetic process
B	0045548	molecular_function	phenylalanine ammonia-lyase activity
B	0051289	biological_process	protein homotetramerization

Functional Information from PROSITE/UniProt

site_id	PS00488
Number of Residues	17
Details	PAL_HISTIDASE Phenylalanine and histidine ammonia-lyases signature. GSVSASGDLiPLAyiaG

Chain	Residue	Details
A	GLY171-LEU189

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:22113970, ECO:0000269|PubMed:24786474

Chain	Residue	Details
A	TYR80
B	TYR80

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site_id	SWS_FT_FI2
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:24786474, ECO:0007744|PDB:4CQ5

Chain	Residue	Details
A	THR233
B	ASP460
A	ARG321
A	SER327
A	ILE357
A	ASP460
B	THR233
B	ARG321
B	SER327
B	ILE357

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P11544

Chain	Residue	Details
A	LEU429
A	HIS457
B	LEU429
B	HIS457

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: 2,3-didehydroalanine (Ser) => ECO:0000269|PubMed:24786474

Chain	Residue	Details
A	ASP178
B	ASP178

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site_id	SWS_FT_FI5
Number of Residues	4
Details	CROSSLNK: 5-imidazolinone (Ala-Gly) => ECO:0000269|PubMed:24786474

Chain	Residue	Details
A	MDO175
A	LEU179
B	MDO175
B	LEU179

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