4UY6
Crystal structure of Histidine and SAH bound Histidine-specific methyltransferase EgtD from Mycobacterium smegmatis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008276 | molecular_function | protein methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0052699 | biological_process | ergothioneine biosynthetic process |
| A | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
| A | 0052706 | molecular_function | L-histidine N(alpha)-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE HIS A 800 |
| Chain | Residue |
| A | TYR56 |
| A | ASN166 |
| A | TYR206 |
| A | GLU282 |
| A | SER284 |
| A | HOH2104 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE SAH A 801 |
| Chain | Residue |
| A | SER87 |
| A | GLY88 |
| A | LYS92 |
| A | ASP113 |
| A | VAL114 |
| A | GLY140 |
| A | ASP141 |
| A | PHE142 |
| A | GLY161 |
| A | HOH2034 |
| A | HOH2044 |
| A | HOH2056 |
| A | TYR39 |
| A | PHE47 |
| A | GLY86 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TRS A 1801 |
| Chain | Residue |
| A | THR68 |
| A | ARG69 |
| A | GLU72 |
| A | ARG108 |
| A | GLU134 |
| A | ASP246 |
| A | HOH2048 |
| A | HOH2116 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TRS A 1802 |
| Chain | Residue |
| A | GLU143 |
| A | GLU144 |
| A | GLU174 |
| A | ASP231 |
| A | HIS261 |
| A | GLU270 |
| A | HOH2072 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TRS A 1803 |
| Chain | Residue |
| A | SER177 |
| A | ASP181 |
| A | ARG263 |
| A | ALA265 |
| A | ASP268 |
| A | ALA299 |
| A | GLY300 |
| A | HOH2131 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25251321","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25404173","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4UY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UY7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25251321","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25404173","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25251321","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25404173","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4PIO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UY6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
