4UY6
Crystal structure of Histidine and SAH bound Histidine-specific methyltransferase EgtD from Mycobacterium smegmatis
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0008276 | molecular_function | protein methyltransferase activity |
A | 0030745 | molecular_function | dimethylhistidine N-methyltransferase activity |
A | 0032259 | biological_process | methylation |
A | 0052699 | biological_process | ergothioneine biosynthetic process |
A | 0052704 | biological_process | ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide |
A | 0052707 | biological_process | N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE HIS A 800 |
Chain | Residue |
A | TYR56 |
A | ASN166 |
A | TYR206 |
A | GLU282 |
A | SER284 |
A | HOH2104 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE SAH A 801 |
Chain | Residue |
A | SER87 |
A | GLY88 |
A | LYS92 |
A | ASP113 |
A | VAL114 |
A | GLY140 |
A | ASP141 |
A | PHE142 |
A | GLY161 |
A | HOH2034 |
A | HOH2044 |
A | HOH2056 |
A | TYR39 |
A | PHE47 |
A | GLY86 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE TRS A 1801 |
Chain | Residue |
A | THR68 |
A | ARG69 |
A | GLU72 |
A | ARG108 |
A | GLU134 |
A | ASP246 |
A | HOH2048 |
A | HOH2116 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE TRS A 1802 |
Chain | Residue |
A | GLU143 |
A | GLU144 |
A | GLU174 |
A | ASP231 |
A | HIS261 |
A | GLU270 |
A | HOH2072 |
site_id | AC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE TRS A 1803 |
Chain | Residue |
A | SER177 |
A | ASP181 |
A | ARG263 |
A | ALA265 |
A | ASP268 |
A | ALA299 |
A | GLY300 |
A | HOH2131 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25251321, ECO:0000305|PubMed:25404173, ECO:0007744|PDB:4UY6, ECO:0007744|PDB:4UY7 |
Chain | Residue | Details |
A | GLU282 | |
A | TYR56 | |
A | ASN166 | |
A | TYR206 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000305|PubMed:25251321, ECO:0000305|PubMed:25404173 |
Chain | Residue | Details |
A | LYS92 | |
A | ASP113 | |
A | GLY86 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000305|PubMed:25251321, ECO:0000305|PubMed:25404173, ECO:0007744|PDB:4PIO, ECO:0007744|PDB:4PIP, ECO:0007744|PDB:4UY6 |
Chain | Residue | Details |
A | ASP141 |