4UY2

Crystal structure of the complex of the extracellular domain of human alpha9 nAChR with alpha-bungarotoxin.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0045211	cellular_component	postsynaptic membrane
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0045211	cellular_component	postsynaptic membrane
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0030550	molecular_function	acetylcholine receptor inhibitor activity
C	0035821	biological_process	modulation of process of another organism
C	0090729	molecular_function	toxin activity
C	0099106	molecular_function	ion channel regulator activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0030550	molecular_function	acetylcholine receptor inhibitor activity
D	0035821	biological_process	modulation of process of another organism
D	0090729	molecular_function	toxin activity
D	0099106	molecular_function	ion channel regulator activity

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CvVdVtyFPfDnqqC

Chain	Residue	Details
A	CYS130-CYS144

---

site_id	PS00272
Number of Residues	21
Details	SNAKE_TOXIN Snake toxins signature. GCaatCPskkpyeevt.CCstD

Chain	Residue	Details
C	GLY43-ASP63

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25282151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UXU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Key residue important for potent inhibition of the CHRNA9:CHRNA10 receptor by the alpha-conotoxin RgIA (AC P0C1D0)","evidences":[{"source":"UniProtKB","id":"P43144","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25282151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4D01","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UXU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UY2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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