Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4UXJ

Leishmania major Thymidine Kinase in complex with dTTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004797	molecular_function	thymidine kinase activity
A	0005524	molecular_function	ATP binding
B	0004797	molecular_function	thymidine kinase activity
B	0005524	molecular_function	ATP binding
C	0004797	molecular_function	thymidine kinase activity
C	0005524	molecular_function	ATP binding
D	0004797	molecular_function	thymidine kinase activity
D	0005524	molecular_function	ATP binding
E	0004797	molecular_function	thymidine kinase activity
E	0005524	molecular_function	ATP binding
F	0004797	molecular_function	thymidine kinase activity
F	0005524	molecular_function	ATP binding
G	0004797	molecular_function	thymidine kinase activity
G	0005524	molecular_function	ATP binding
H	0004797	molecular_function	thymidine kinase activity
H	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1183

Chain	Residue
A	CYS140
A	CYS143
A	CYS173
A	CYS176

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1180

Chain	Residue
B	CYS140
B	CYS143
B	CYS173
B	CYS176

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1180

Chain	Residue
C	CYS143
C	CYS173
C	CYS176
C	CYS140

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1180

Chain	Residue
E	CYS140
E	CYS143
E	CYS173
E	CYS176

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 1182

Chain	Residue
F	CYS140
F	CYS143
F	CYS173
F	CYS176

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 1180

Chain	Residue
G	CYS140
G	CYS143
G	CYS173
G	CYS176

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 1178

Chain	Residue
H	CYS140
H	CYS143
H	CYS173
H	CYS176

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1180

Chain	Residue
D	CYS140
D	CYS143
D	CYS173
D	CYS176

site_id	AC9
Number of Residues	19
Details	BINDING SITE FOR RESIDUE TTP D 1181

Chain	Residue
D	MET13
D	PHE14
D	ALA15
D	GLY16
D	LYS17
D	THR18
D	GLU85
D	GLN87
D	PHE88
D	LEU111
D	ASP114
D	TYR115
D	THR151
D	GLN160
D	GLU161
D	LEU162
D	GLY164
D	TYR169
D	MG1182

site_id	BC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE TTP C 1181

Chain	Residue
C	MET13
C	PHE14
C	ALA15
C	GLY16
C	LYS17
C	THR18
C	GLU85
C	GLN87
C	PHE88
C	LEU111
C	ASP114
C	TYR115
C	PHE120
C	THR151
C	GLN160
C	GLU161
C	LEU162
C	GLY164
C	TYR169
C	MG1182
C	HOH2012
C	HOH2013

site_id	BC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE TTP A 1184

Chain	Residue
A	MET13
A	PHE14
A	ALA15
A	GLY16
A	LYS17
A	THR18
A	GLU85
A	PHE88
A	LEU111
A	ASP114
A	TYR115
A	THR151
A	GLN160
A	GLU161
A	LEU162
A	ILE163
A	GLY164
A	TYR169
A	MG1185
A	HOH2013

site_id	BC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE TTP H 1179

Chain	Residue
H	PHE88
H	LEU111
H	ASP114
H	TYR115
H	PHE120
H	GLN160
H	GLU161
H	LEU162
H	GLY164
H	TYR169
H	MG1180
H	MET13
H	PHE14
H	ALA15
H	GLY16
H	LYS17
H	THR18

site_id	BC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE TTP G 1181

Chain	Residue
G	PHE14
G	ALA15
G	GLY16
G	LYS17
G	THR18
G	GLU85
G	GLN87
G	PHE88
G	LEU111
G	ASP114
G	TYR115
G	THR151
G	GLN160
G	GLU161
G	LEU162
G	GLY164
G	TYR169
G	MG1182

site_id	BC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE TTP E 1181

Chain	Residue
E	MET13
E	PHE14
E	ALA15
E	GLY16
E	LYS17
E	THR18
E	GLU85
E	PHE88
E	LEU111
E	ASP114
E	TYR115
E	THR151
E	GLN160
E	GLU161
E	LEU162
E	GLY164
E	TYR169
E	MG1182

site_id	BC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE TTP B 1181

Chain	Residue
B	MET13
B	PHE14
B	ALA15
B	GLY16
B	LYS17
B	THR18
B	GLU85
B	PHE88
B	LEU111
B	ASP114
B	TYR115
B	PHE120
B	THR151
B	GLN160
B	GLU161
B	LEU162
B	GLY164
B	TYR169
B	MG1182

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TTP F 1183

Chain	Residue
F	MET13
F	PHE14
F	ALA15
F	GLY16
F	LYS17
F	THR18
F	GLU85
F	MG1184

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 1182

Chain	Residue
C	THR18
C	TTP1181

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 1185

Chain	Residue
A	THR18
A	TTP1184

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG H 1180

Chain	Residue
H	THR18
H	TTP1179

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG G 1182

Chain	Residue
G	THR18
G	TTP1181

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 1182

Chain	Residue
B	THR18
B	TTP1181

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D 1182

Chain	Residue
D	THR18
D	TTP1181

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG E 1182

Chain	Residue
E	THR18
E	TTP1181

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG F 1184

Chain	Residue
F	THR18
F	TTP1183

Functional Information from PROSITE/UniProt

site_id	PS00603
Number of Residues	14
Details	TK_CELLULAR_TYPE Thymidine kinase cellular-type signature. GgaDmYiAtCReCY

Chain	Residue	Details
A	GLY164-TYR177

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)