4UWI

Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
A	0006499	biological_process	N-terminal protein myristoylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE XMQ A 1493

Chain	Residue
A	VAL148
A	SER378
A	TYR393
A	GLY455
A	LEU492
A	HOH2077
A	HOH2206
A	HOH2226
A	HOH2329
A	HOH2391
A	ASP150
A	PHE155
A	ARG156
A	PHE157
A	ASN213
A	THR249
A	TYR263
A	HIS265

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site_id	AC2
Number of Residues	30
Details	BINDING SITE FOR RESIDUE MYA A 1494

Chain	Residue
A	HIS146
A	TYR147
A	VAL148
A	ASN213
A	PHE214
A	LEU215
A	CYS216
A	ILE217
A	ARG222
A	SER223
A	LYS224
A	ARG225
A	LEU226
A	THR227
A	THR235
A	CYS238
A	TYR244
A	TYR248
A	THR249
A	LEU254
A	TYR462
A	HOH2181
A	HOH2184
A	HOH2393
A	HOH2394
A	HOH2395
A	HOH2396
A	HOH2397
A	HOH2398
A	HOH2399

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Functional Information from PROSITE/UniProt

site_id	PS00975
Number of Residues	9
Details	NMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EINFLCiHK

Chain	Residue	Details
A	GLU211-LYS219

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site_id	PS00976
Number of Residues	7
Details	NMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGaGDG

Chain	Residue	Details
A	LYS449-GLY455

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor; via carboxylate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P14743","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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