4UUP
Reconstructed ancestral trichomonad malate dehydrogenase in complex with NADH, SO4, and PO4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0006108 | biological_process | malate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016615 | molecular_function | malate dehydrogenase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0006108 | biological_process | malate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016615 | molecular_function | malate dehydrogenase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CYS A 250 |
| Chain | Residue |
| A | ARG156 |
| A | ASN246 |
| A | ALA247 |
| A | ALA248 |
| A | LEU249 |
| A | HIS251 |
| A | MET252 |
| A | ARG253 |
| A | ASP254 |
| site_id | AC2 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NAI A 345 |
| Chain | Residue |
| A | GLY11 |
| A | GLY14 |
| A | GLN15 |
| A | ILE16 |
| A | LEU40 |
| A | GLU41 |
| A | ILE42 |
| A | VAL86 |
| A | GLY87 |
| A | SER88 |
| A | PHE89 |
| A | PRO90 |
| A | ILE107 |
| A | GLN111 |
| A | VAL128 |
| A | GLY129 |
| A | ASN130 |
| A | MET154 |
| A | HIS186 |
| A | SER239 |
| A | SER240 |
| A | PO4346 |
| A | HOH2010 |
| A | HOH2124 |
| A | HOH2128 |
| A | HOH2195 |
| A | HOH2353 |
| A | HOH2354 |
| A | HOH2355 |
| A | HOH2357 |
| A | HOH2358 |
| A | HOH2359 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 346 |
| Chain | Residue |
| A | ARG91 |
| A | ARG97 |
| A | ASN130 |
| A | ARG161 |
| A | HIS186 |
| A | GLY229 |
| A | NAI345 |
| A | HOH2205 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CYS B 250 |
| Chain | Residue |
| B | ARG156 |
| B | ASN246 |
| B | ALA247 |
| B | ALA248 |
| B | LEU249 |
| B | HIS251 |
| B | MET252 |
| B | ARG253 |
| B | ASP254 |
| site_id | AC5 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAI B 345 |
| Chain | Residue |
| B | GLY11 |
| B | GLY14 |
| B | GLN15 |
| B | ILE16 |
| B | GLU41 |
| B | ILE42 |
| B | ALA45 |
| B | VAL86 |
| B | GLY87 |
| B | SER88 |
| B | ILE107 |
| B | GLN111 |
| B | VAL128 |
| B | GLY129 |
| B | ASN130 |
| B | MET154 |
| B | LEU157 |
| B | HIS186 |
| B | SER239 |
| B | SER240 |
| B | ALA244 |
| B | SO4346 |
| B | HOH2008 |
| B | HOH2121 |
| B | HOH2233 |
| B | HOH2234 |
| B | HOH2236 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 346 |
| Chain | Residue |
| B | ASN130 |
| B | ARG161 |
| B | HIS186 |
| B | SER240 |
| B | NAI345 |
| B | HOH2179 |
| B | HOH2237 |
Functional Information from PROSITE/UniProt
| site_id | PS00068 |
| Number of Residues | 13 |
| Details | MDH Malate dehydrogenase active site signature. MTRLDhnRAigeI |
| Chain | Residue | Details |
| A | MET154-ILE166 |
