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4UU8

Crystal structure of zebrafish Sirtuin 5 in complex with 3,3-dimethyl- succinylated CPS1-peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0036054molecular_functionprotein-malonyllysine demalonylase activity
A0036055molecular_functionprotein-succinyllysine desuccinylase activity
A0070403molecular_functionNAD+ binding
B0036054molecular_functionprotein-malonyllysine demalonylase activity
B0036055molecular_functionprotein-succinyllysine desuccinylase activity
B0070403molecular_functionNAD+ binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1299
ChainResidue
ACYS162
ACYS165
ACYS203
ACYS208

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 1299
ChainResidue
BCYS162
BCYS165
BCYS203
BCYS208

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE WOC A 1300
ChainResidue
ATYR98
AARG101
AHIS154
AVAL217
DLYS4
AALA82

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE EPE B 1300
ChainResidue
ATHR229
AGLU232
BALA78
BALA82
BARG101
BHIS154
BVAL217
BPHE219
BGLU221
BEDO1301

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE DMS A 1301
ChainResidue
AARG144
AALA145
AGLY146
AHOH2039
BARG144
BALA145

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 1301
ChainResidue
BGLN136
BASN137
BILE138
BHIS154
BEPE1300

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NA B 1302
ChainResidue
BASP224
BASP224
BASP226
BASP226

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q8C196
ChainResidueDetails
DLYS4
BHIS154

site_idSWS_FT_FI2
Number of Residues22
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160
ChainResidueDetails
AGLY54
AASN271
ACYS289
BGLY54
BTYR98
BARG101
BGLN136
BCYS162
BCYS165
BCYS203
BCYS208
ATYR98
BGLY245
BASN271
BCYS289
AARG101
AGLN136
ACYS162
ACYS165
ACYS203
ACYS208
AGLY245

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PDB entries from 2024-10-30

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