4USV
Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate resulting from soaking with ATP and Calcium
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1467 |
| Chain | Residue |
| A | LYS95 |
| A | VAL167 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 1468 |
| Chain | Residue |
| A | ASP47 |
| A | ASP99 |
| A | POP1472 |
| A | HOH2034 |
| A | HOH2064 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1469 |
| Chain | Residue |
| A | GLU288 |
| A | ARG290 |
| A | PRO351 |
| A | CYS393 |
| A | TYR404 |
| A | TYR285 |
| A | LEU286 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 1470 |
| Chain | Residue |
| A | HIS238 |
| A | TYR239 |
| A | LEU251 |
| A | PHE442 |
| A | LYS443 |
| A | GLU444 |
| A | HOH2177 |
| A | HOH2184 |
| A | HOH2185 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 1471 |
| Chain | Residue |
| A | LYS95 |
| A | HIS164 |
| A | PHE165 |
| A | LYS334 |
| A | VAL335 |
| A | HOH2087 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE POP A 1472 |
| Chain | Residue |
| A | ASP47 |
| A | ILE48 |
| A | SER49 |
| A | GLY50 |
| A | PHE51 |
| A | THR52 |
| A | ASP99 |
| A | ASN412 |
| A | CA1468 |
| A | HOH2035 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1473 |
| Chain | Residue |
| A | PHE29 |
| A | SER30 |
| A | PRO31 |
| A | ARG33 |
| A | SER264 |
| A | HOH2029 |
| A | HOH2124 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00099 |
| Chain | Residue | Details |
| A | ASP47 | |
| A | ILE48 | |
| A | ASP99 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24567411, ECO:0000269|PubMed:24616449, ECO:0007744|PDB:4CLL, ECO:0007744|PDB:4OYZ |
| Chain | Residue | Details |
| A | LYS95 | |
| A | VAL167 | |
| A | ARG176 | |
| A | MET337 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25040695, ECO:0000305|PubMed:24567411, ECO:0000305|PubMed:24616449, ECO:0007744|PDB:4USW |
| Chain | Residue | Details |
| A | LYS144 | |
| A | VAL406 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:24567411, ECO:0000305|PubMed:24616449, ECO:0000305|PubMed:25040695 |
| Chain | Residue | Details |
| A | ASN412 |
