4USV
Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate resulting from soaking with ATP and Calcium
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1467 |
| Chain | Residue |
| A | LYS95 |
| A | VAL167 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 1468 |
| Chain | Residue |
| A | ASP47 |
| A | ASP99 |
| A | POP1472 |
| A | HOH2034 |
| A | HOH2064 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1469 |
| Chain | Residue |
| A | GLU288 |
| A | ARG290 |
| A | PRO351 |
| A | CYS393 |
| A | TYR404 |
| A | TYR285 |
| A | LEU286 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 1470 |
| Chain | Residue |
| A | HIS238 |
| A | TYR239 |
| A | LEU251 |
| A | PHE442 |
| A | LYS443 |
| A | GLU444 |
| A | HOH2177 |
| A | HOH2184 |
| A | HOH2185 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 1471 |
| Chain | Residue |
| A | LYS95 |
| A | HIS164 |
| A | PHE165 |
| A | LYS334 |
| A | VAL335 |
| A | HOH2087 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE POP A 1472 |
| Chain | Residue |
| A | ASP47 |
| A | ILE48 |
| A | SER49 |
| A | GLY50 |
| A | PHE51 |
| A | THR52 |
| A | ASP99 |
| A | ASN412 |
| A | CA1468 |
| A | HOH2035 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1473 |
| Chain | Residue |
| A | PHE29 |
| A | SER30 |
| A | PRO31 |
| A | ARG33 |
| A | SER264 |
| A | HOH2029 |
| A | HOH2124 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 125 |
| Details | Domain: {"description":"Guanylate cyclase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4USW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OYZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
