4USL
The X-ray structure of calcium bound human sorcin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002020 | molecular_function | protease binding |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005246 | molecular_function | calcium channel regulator activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0010459 | biological_process | negative regulation of heart rate |
| A | 0010468 | biological_process | regulation of gene expression |
| A | 0010649 | biological_process | regulation of cell communication by electrical coupling |
| A | 0010880 | biological_process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| A | 0016020 | cellular_component | membrane |
| A | 0016529 | cellular_component | sarcoplasmic reticulum |
| A | 0030018 | cellular_component | Z disc |
| A | 0030315 | cellular_component | T-tubule |
| A | 0031982 | cellular_component | vesicle |
| A | 0033017 | cellular_component | sarcoplasmic reticulum membrane |
| A | 0042584 | cellular_component | chromaffin granule membrane |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| A | 0051281 | biological_process | positive regulation of release of sequestered calcium ion into cytosol |
| A | 0051924 | biological_process | regulation of calcium ion transport |
| A | 0055118 | biological_process | negative regulation of cardiac muscle contraction |
| A | 0061178 | biological_process | regulation of insulin secretion involved in cellular response to glucose stimulus |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0086004 | biological_process | regulation of cardiac muscle cell contraction |
| A | 0140297 | molecular_function | DNA-binding transcription factor binding |
| A | 0140311 | molecular_function | protein sequestering activity |
| A | 0140416 | molecular_function | transcription regulator inhibitor activity |
| A | 1901077 | biological_process | regulation of relaxation of muscle |
| A | 1901844 | biological_process | regulation of cell communication by electrical coupling involved in cardiac conduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1199 |
| Chain | Residue |
| A | ASP113 |
| A | ASP115 |
| A | SER117 |
| A | THR119 |
| A | GLU124 |
| A | HOH2076 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1200 |
| Chain | Residue |
| A | GLU53 |
| A | HOH2010 |
| A | HOH2016 |
| A | ALA43 |
| A | ASP46 |
| A | GLN48 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1201 |
| Chain | Residue |
| A | ASP83 |
| A | ASP85 |
| A | SER87 |
| A | THR89 |
| A | GLU94 |
| A | HOH2019 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1202 |
| Chain | Residue |
| A | SER172 |
| A | ARG175 |
| A | ARG176 |
| A | CYS194 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG A 1203 |
| Chain | Residue |
| A | GLN48 |
| A | GLY91 |
| A | PHE92 |
| A | ASN93 |
| A | GLU94 |
| A | HOH2019 |
| A | HOH2063 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEG A 1204 |
| Chain | Residue |
| A | GLY37 |
| A | TYR38 |
| A | ALA41 |
| A | VAL42 |
| A | GLU53 |
| A | ARG56 |
| A | CYS57 |
| A | GLN60 |
| A | SER61 |
| A | HOH2008 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DRDMSGTMGfnEF |
| Chain | Residue | Details |
| A | ASP83-PHE95 | |
| A | ASP113-LEU125 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
