Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4UQV

methanococcus jannaschii serine hydroxymethyl-transferase in complex with PLP

Replaces: 4BHE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004372	molecular_function	glycine hydroxymethyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006545	biological_process	glycine biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0008732	molecular_function	L-allo-threonine aldolase activity
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0019264	biological_process	glycine biosynthetic process from serine
A	0030170	molecular_function	pyridoxal phosphate binding
A	0035999	biological_process	tetrahydrofolate interconversion
A	0046653	biological_process	tetrahydrofolate metabolic process
B	0004372	molecular_function	glycine hydroxymethyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006545	biological_process	glycine biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0008732	molecular_function	L-allo-threonine aldolase activity
B	0016740	molecular_function	transferase activity
B	0016829	molecular_function	lyase activity
B	0019264	biological_process	glycine biosynthetic process from serine
B	0030170	molecular_function	pyridoxal phosphate binding
B	0035999	biological_process	tetrahydrofolate interconversion
B	0046653	biological_process	tetrahydrofolate metabolic process
C	0004372	molecular_function	glycine hydroxymethyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006545	biological_process	glycine biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0008732	molecular_function	L-allo-threonine aldolase activity
C	0016740	molecular_function	transferase activity
C	0016829	molecular_function	lyase activity
C	0019264	biological_process	glycine biosynthetic process from serine
C	0030170	molecular_function	pyridoxal phosphate binding
C	0035999	biological_process	tetrahydrofolate interconversion
C	0046653	biological_process	tetrahydrofolate metabolic process
D	0004372	molecular_function	glycine hydroxymethyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006545	biological_process	glycine biosynthetic process
D	0006730	biological_process	one-carbon metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0008732	molecular_function	L-allo-threonine aldolase activity
D	0016740	molecular_function	transferase activity
D	0016829	molecular_function	lyase activity
D	0019264	biological_process	glycine biosynthetic process from serine
D	0030170	molecular_function	pyridoxal phosphate binding
D	0035999	biological_process	tetrahydrofolate interconversion
D	0046653	biological_process	tetrahydrofolate metabolic process
E	0004372	molecular_function	glycine hydroxymethyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006545	biological_process	glycine biosynthetic process
E	0006730	biological_process	one-carbon metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0008732	molecular_function	L-allo-threonine aldolase activity
E	0016740	molecular_function	transferase activity
E	0016829	molecular_function	lyase activity
E	0019264	biological_process	glycine biosynthetic process from serine
E	0030170	molecular_function	pyridoxal phosphate binding
E	0035999	biological_process	tetrahydrofolate interconversion
E	0046653	biological_process	tetrahydrofolate metabolic process
F	0004372	molecular_function	glycine hydroxymethyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006545	biological_process	glycine biosynthetic process
F	0006730	biological_process	one-carbon metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0008732	molecular_function	L-allo-threonine aldolase activity
F	0016740	molecular_function	transferase activity
F	0016829	molecular_function	lyase activity
F	0019264	biological_process	glycine biosynthetic process from serine
F	0030170	molecular_function	pyridoxal phosphate binding
F	0035999	biological_process	tetrahydrofolate interconversion
F	0046653	biological_process	tetrahydrofolate metabolic process
G	0004372	molecular_function	glycine hydroxymethyltransferase activity
G	0005737	cellular_component	cytoplasm
G	0006545	biological_process	glycine biosynthetic process
G	0006730	biological_process	one-carbon metabolic process
G	0008652	biological_process	amino acid biosynthetic process
G	0008732	molecular_function	L-allo-threonine aldolase activity
G	0016740	molecular_function	transferase activity
G	0016829	molecular_function	lyase activity
G	0019264	biological_process	glycine biosynthetic process from serine
G	0030170	molecular_function	pyridoxal phosphate binding
G	0035999	biological_process	tetrahydrofolate interconversion
G	0046653	biological_process	tetrahydrofolate metabolic process
H	0004372	molecular_function	glycine hydroxymethyltransferase activity
H	0005737	cellular_component	cytoplasm
H	0006545	biological_process	glycine biosynthetic process
H	0006730	biological_process	one-carbon metabolic process
H	0008652	biological_process	amino acid biosynthetic process
H	0008732	molecular_function	L-allo-threonine aldolase activity
H	0016740	molecular_function	transferase activity
H	0016829	molecular_function	lyase activity
H	0019264	biological_process	glycine biosynthetic process from serine
H	0030170	molecular_function	pyridoxal phosphate binding
H	0035999	biological_process	tetrahydrofolate interconversion
H	0046653	biological_process	tetrahydrofolate metabolic process
I	0004372	molecular_function	glycine hydroxymethyltransferase activity
I	0005737	cellular_component	cytoplasm
I	0006545	biological_process	glycine biosynthetic process
I	0006730	biological_process	one-carbon metabolic process
I	0008652	biological_process	amino acid biosynthetic process
I	0008732	molecular_function	L-allo-threonine aldolase activity
I	0016740	molecular_function	transferase activity
I	0016829	molecular_function	lyase activity
I	0019264	biological_process	glycine biosynthetic process from serine
I	0030170	molecular_function	pyridoxal phosphate binding
I	0035999	biological_process	tetrahydrofolate interconversion
I	0046653	biological_process	tetrahydrofolate metabolic process
J	0004372	molecular_function	glycine hydroxymethyltransferase activity
J	0005737	cellular_component	cytoplasm
J	0006545	biological_process	glycine biosynthetic process
J	0006730	biological_process	one-carbon metabolic process
J	0008652	biological_process	amino acid biosynthetic process
J	0008732	molecular_function	L-allo-threonine aldolase activity
J	0016740	molecular_function	transferase activity
J	0016829	molecular_function	lyase activity
J	0019264	biological_process	glycine biosynthetic process from serine
J	0030170	molecular_function	pyridoxal phosphate binding
J	0035999	biological_process	tetrahydrofolate interconversion
J	0046653	biological_process	tetrahydrofolate metabolic process
K	0004372	molecular_function	glycine hydroxymethyltransferase activity
K	0005737	cellular_component	cytoplasm
K	0006545	biological_process	glycine biosynthetic process
K	0006730	biological_process	one-carbon metabolic process
K	0008652	biological_process	amino acid biosynthetic process
K	0008732	molecular_function	L-allo-threonine aldolase activity
K	0016740	molecular_function	transferase activity
K	0016829	molecular_function	lyase activity
K	0019264	biological_process	glycine biosynthetic process from serine
K	0030170	molecular_function	pyridoxal phosphate binding
K	0035999	biological_process	tetrahydrofolate interconversion
K	0046653	biological_process	tetrahydrofolate metabolic process
L	0004372	molecular_function	glycine hydroxymethyltransferase activity
L	0005737	cellular_component	cytoplasm
L	0006545	biological_process	glycine biosynthetic process
L	0006730	biological_process	one-carbon metabolic process
L	0008652	biological_process	amino acid biosynthetic process
L	0008732	molecular_function	L-allo-threonine aldolase activity
L	0016740	molecular_function	transferase activity
L	0016829	molecular_function	lyase activity
L	0019264	biological_process	glycine biosynthetic process from serine
L	0030170	molecular_function	pyridoxal phosphate binding
L	0035999	biological_process	tetrahydrofolate interconversion
L	0046653	biological_process	tetrahydrofolate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLP A 1430

Chain	Residue
A	SER92
A	LYS226
A	GLY233
B	TYR50
B	SER256
B	ASN257
A	GLY93
A	VAL94
A	ASN97
A	HIS124
A	ASP196
A	ALA198
A	SER223
A	HIS225

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PLP B 1430

Chain	Residue
A	TYR50
A	SER256
A	ASN257
B	SER92
B	GLY93
B	VAL94
B	HIS121
B	HIS124
B	GLY170
B	SER171
B	ASP196
B	HIS199
B	SER223
B	HIS225
B	LYS226

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PLP C 1430

Chain	Residue
C	SER92
C	GLY93
C	VAL94
C	ASN97
C	HIS121
C	HIS124
C	GLY170
C	ASP196
C	ALA198
C	HIS199
C	SER223
C	HIS225
C	LYS226
D	TYR50
D	VAL255
D	SER256
D	ASN257

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP D 1430

Chain	Residue
C	GLU52
C	TYR60
D	SER30
D	GLY93
D	VAL94
D	HIS121
D	SER171
D	ALA198
D	HIS199
D	SER223
D	HIS225
D	LYS226
D	ARG363

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PLP E 1430

Chain	Residue
E	SER92
E	GLY93
E	VAL94
E	HIS121
E	GLY170
E	ASP196
E	GLY197
E	ALA198
E	HIS199
E	SER223
E	HIS225
E	LYS226
F	TYR50
F	SER256
F	ASN257

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PLP F 1430

Chain	Residue
E	TYR50
E	SER256
E	ASN257
F	SER92
F	GLY93
F	VAL94
F	HIS121
F	GLY170
F	HIS199
F	SER223
F	HIS225
F	LYS226

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP G 1430

Chain	Residue
G	SER92
G	GLY93
G	VAL94
G	HIS121
G	ASP196
G	ALA198
G	HIS199
G	SER223
G	HIS225
G	LYS226
H	TYR50
H	SER256
H	ASN257

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PLP H 1430

Chain	Residue
G	TYR50
G	ASN257
H	SER92
H	GLY93
H	VAL94
H	HIS121
H	GLY170
H	ALA198
H	HIS199
H	SER223
H	HIS225
H	LYS226

site_id	AC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PLP I 1430

Chain	Residue
I	SER92
I	GLY93
I	VAL94
I	HIS121
I	ASP196
I	ALA198
I	HIS199
I	SER223
I	HIS225
I	LYS226
J	SER256
J	ASN257

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLP J 1430

Chain	Residue
I	TYR50
I	SER256
I	ASN257
J	SER92
J	GLY93
J	HIS121
J	GLY170
J	SER171
J	ASP196
J	ALA198
J	HIS199
J	SER223
J	HIS225
J	LYS226

site_id	BC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP K 1430

Chain	Residue
K	SER92
K	GLY93
K	VAL94
K	ASN97
K	HIS121
K	ASP196
K	SER223
K	HIS225
K	LYS226
K	GLN232
L	TYR50
L	VAL255
L	HIS259

site_id	BC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP L 1430

Chain	Residue
K	TYR50
L	SER92
L	GLY93
L	VAL94
L	HIS121
L	SER123
L	HIS124
L	GLY170
L	ASP196
L	ALA198
L	SER223
L	HIS225
L	LYS226

Functional Information from PROSITE/UniProt

site_id	PS00096
Number of Residues	17
Details	SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. EYlMGSTHKTFfGPQGG

Chain	Residue	Details
A	GLU218-GLY234

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00051","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Site: {"description":"Plays an important role in substrate specificity","evidences":[{"source":"HAMAP-Rule","id":"MF_00051","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"HAMAP-Rule","id":"MF_00051","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)