4UQF

CRYSTAL STRUCTURE OF LISTERIA MONOCYTOGENES GTP CYCLOHYDROLASE I

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0006729	biological_process	tetrahydrobiopterin biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0018130	biological_process	obsolete heterocycle biosynthetic process
A	0019438	biological_process	obsolete aromatic compound biosynthetic process
A	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046872	molecular_function	metal ion binding
A	1901362	biological_process	organic cyclic compound biosynthetic process
A	1901566	biological_process	organonitrogen compound biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0006729	biological_process	tetrahydrobiopterin biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0018130	biological_process	obsolete heterocycle biosynthetic process
B	0019438	biological_process	obsolete aromatic compound biosynthetic process
B	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046872	molecular_function	metal ion binding
B	1901362	biological_process	organic cyclic compound biosynthetic process
B	1901566	biological_process	organonitrogen compound biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0006729	biological_process	tetrahydrobiopterin biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0018130	biological_process	obsolete heterocycle biosynthetic process
C	0019438	biological_process	obsolete aromatic compound biosynthetic process
C	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
C	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0046872	molecular_function	metal ion binding
C	1901362	biological_process	organic cyclic compound biosynthetic process
C	1901566	biological_process	organonitrogen compound biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0006729	biological_process	tetrahydrobiopterin biosynthetic process
D	0006730	biological_process	one-carbon metabolic process
D	0008270	molecular_function	zinc ion binding
D	0016787	molecular_function	hydrolase activity
D	0018130	biological_process	obsolete heterocycle biosynthetic process
D	0019438	biological_process	obsolete aromatic compound biosynthetic process
D	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
D	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0046872	molecular_function	metal ion binding
D	1901362	biological_process	organic cyclic compound biosynthetic process
D	1901566	biological_process	organonitrogen compound biosynthetic process
E	0000166	molecular_function	nucleotide binding
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0006729	biological_process	tetrahydrobiopterin biosynthetic process
E	0006730	biological_process	one-carbon metabolic process
E	0008270	molecular_function	zinc ion binding
E	0016787	molecular_function	hydrolase activity
E	0018130	biological_process	obsolete heterocycle biosynthetic process
E	0019438	biological_process	obsolete aromatic compound biosynthetic process
E	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
E	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0046872	molecular_function	metal ion binding
E	1901362	biological_process	organic cyclic compound biosynthetic process
E	1901566	biological_process	organonitrogen compound biosynthetic process
F	0000166	molecular_function	nucleotide binding
F	0003934	molecular_function	GTP cyclohydrolase I activity
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0006729	biological_process	tetrahydrobiopterin biosynthetic process
F	0006730	biological_process	one-carbon metabolic process
F	0008270	molecular_function	zinc ion binding
F	0016787	molecular_function	hydrolase activity
F	0018130	biological_process	obsolete heterocycle biosynthetic process
F	0019438	biological_process	obsolete aromatic compound biosynthetic process
F	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
F	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0046872	molecular_function	metal ion binding
F	1901362	biological_process	organic cyclic compound biosynthetic process
F	1901566	biological_process	organonitrogen compound biosynthetic process
G	0000166	molecular_function	nucleotide binding
G	0003934	molecular_function	GTP cyclohydrolase I activity
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0006729	biological_process	tetrahydrobiopterin biosynthetic process
G	0006730	biological_process	one-carbon metabolic process
G	0008270	molecular_function	zinc ion binding
G	0016787	molecular_function	hydrolase activity
G	0018130	biological_process	obsolete heterocycle biosynthetic process
G	0019438	biological_process	obsolete aromatic compound biosynthetic process
G	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
G	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0046872	molecular_function	metal ion binding
G	1901362	biological_process	organic cyclic compound biosynthetic process
G	1901566	biological_process	organonitrogen compound biosynthetic process
H	0000166	molecular_function	nucleotide binding
H	0003934	molecular_function	GTP cyclohydrolase I activity
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0006729	biological_process	tetrahydrobiopterin biosynthetic process
H	0006730	biological_process	one-carbon metabolic process
H	0008270	molecular_function	zinc ion binding
H	0016787	molecular_function	hydrolase activity
H	0018130	biological_process	obsolete heterocycle biosynthetic process
H	0019438	biological_process	obsolete aromatic compound biosynthetic process
H	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
H	0046654	biological_process	tetrahydrofolate biosynthetic process
H	0046872	molecular_function	metal ion binding
H	1901362	biological_process	organic cyclic compound biosynthetic process
H	1901566	biological_process	organonitrogen compound biosynthetic process
I	0000166	molecular_function	nucleotide binding
I	0003934	molecular_function	GTP cyclohydrolase I activity
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0006729	biological_process	tetrahydrobiopterin biosynthetic process
I	0006730	biological_process	one-carbon metabolic process
I	0008270	molecular_function	zinc ion binding
I	0016787	molecular_function	hydrolase activity
I	0018130	biological_process	obsolete heterocycle biosynthetic process
I	0019438	biological_process	obsolete aromatic compound biosynthetic process
I	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
I	0046654	biological_process	tetrahydrofolate biosynthetic process
I	0046872	molecular_function	metal ion binding
I	1901362	biological_process	organic cyclic compound biosynthetic process
I	1901566	biological_process	organonitrogen compound biosynthetic process
J	0000166	molecular_function	nucleotide binding
J	0003934	molecular_function	GTP cyclohydrolase I activity
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0006729	biological_process	tetrahydrobiopterin biosynthetic process
J	0006730	biological_process	one-carbon metabolic process
J	0008270	molecular_function	zinc ion binding
J	0016787	molecular_function	hydrolase activity
J	0018130	biological_process	obsolete heterocycle biosynthetic process
J	0019438	biological_process	obsolete aromatic compound biosynthetic process
J	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
J	0046654	biological_process	tetrahydrofolate biosynthetic process
J	0046872	molecular_function	metal ion binding
J	1901362	biological_process	organic cyclic compound biosynthetic process
J	1901566	biological_process	organonitrogen compound biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00859
Number of Residues	17
Details	GTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. ELVlvKDIrfsSmCEHH

Chain	Residue	Details
A	GLU65-HIS81

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site_id	PS00860
Number of Residues	11
Details	GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. SrRpQLQERIT

Chain	Residue	Details
A	SER114-THR124

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00223

Chain	Residue	Details
A	CYS78
D	CYS78
D	HIS81
D	CYS150
E	CYS78
E	HIS81
E	CYS150
F	CYS78
F	HIS81
F	CYS150
G	CYS78
A	HIS81
G	HIS81
G	CYS150
H	CYS78
H	HIS81
H	CYS150
I	CYS78
I	HIS81
I	CYS150
J	CYS78
J	HIS81
A	CYS150
J	CYS150
B	CYS78
B	HIS81
B	CYS150
C	CYS78
C	HIS81
C	CYS150

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