4UMV
CRYSTAL STRUCTURE OF A ZINC-TRANSPORTING PIB-TYPE ATPASE IN THE E2P STATE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005215 | molecular_function | transporter activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006829 | biological_process | zinc ion transport |
| A | 0008551 | molecular_function | P-type cadmium transporter activity |
| A | 0015086 | molecular_function | cadmium ion transmembrane transporter activity |
| A | 0015662 | molecular_function | P-type ion transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016463 | molecular_function | P-type zinc transporter activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0019829 | molecular_function | ATPase-coupled monoatomic cation transmembrane transporter activity |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030001 | biological_process | metal ion transport |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070574 | biological_process | cadmium ion transmembrane transport |
| A | 0071577 | biological_process | zinc ion transmembrane transport |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1731 |
| Chain | Residue |
| A | ASP436 |
| A | THR438 |
| A | ASP628 |
| A | GLY629 |
| A | BEF1732 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BEF A 1732 |
| Chain | Residue |
| A | THR583 |
| A | ASP628 |
| A | ASN631 |
| A | MG1731 |
| A | SER285 |
| A | GLY289 |
| A | ASP436 |
| A | THR438 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VLADTGATVLVT |
| Chain | Residue | Details |
| A | VAL711-THR722 |
| site_id | PS00154 |
| Number of Residues | 7 |
| Details | ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT |
| Chain | Residue | Details |
| A | ASP436-THR442 |
| site_id | PS01047 |
| Number of Residues | 30 |
| Details | HMA_1 Heavy-metal-associated domain. VsGMdCaACarkVEnaVrqlagvnqvq.VlF |
| Chain | Residue | Details |
| A | VAL54-PHE83 |
| site_id | PS01229 |
| Number of Residues | 23 |
| Details | COF_2 Hypothetical cof family signature 2. VGDGiNDapaMkaAaiGiaMgsG |
| Chain | Residue | Details |
| A | VAL626-GLY648 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 133 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 424 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"source":"PubMed","id":"25132545","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P37617","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25132545","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P37617","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"25132545","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for metal transport","evidences":[{"source":"PubMed","id":"25132545","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
