4UHW

Human aldehyde oxidase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004031	molecular_function	aldehyde oxidase activity
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043546	molecular_function	molybdopterin cofactor binding
A	0046872	molecular_function	metal ion binding
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0051287	molecular_function	NAD binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
A	0070062	cellular_component	extracellular exosome
A	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES A 3001

Chain	Residue
A	GLN113
A	CYS114
A	GLY115
A	CYS117
A	CYS149
A	ARG150
A	CYS151
A	MET753

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES A 3002

Chain	Residue
A	CYS44
A	GLY45
A	GLY47
A	CYS49
A	GLY50
A	CYS52
A	CYS74
A	GLY43

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE MTE A 3003

Chain	Residue
A	GLN113
A	CYS151
A	GLY805
A	ALA806
A	PHE807
A	ARG921
A	MET1047
A	GLY1048
A	GLN1049
A	GLY1087
A	GLY1088
A	SER1089
A	VAL1090
A	VAL1091
A	ALA1092
A	GLN1203
A	LEU1268
A	MOS3004

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MOS A 3004

Chain	Residue
A	GLN776
A	GLY808
A	PHE920
A	ARG921
A	GLY1087
A	GLY1088
A	GLU1270
A	MTE3003

---

site_id	AC5
Number of Residues	24
Details	BINDING SITE FOR RESIDUE FAD A 3006

Chain	Residue
A	GLY46
A	GLY47
A	PRO263
A	VAL264
A	MET266
A	GLY267
A	ASN268
A	THR269
A	SER270
A	VAL271
A	LEU344
A	ALA345
A	ALA353
A	SER354
A	GLY357
A	HIS358
A	ILE360
A	SER361
A	HIS363
A	SER366
A	ASP367
A	ILE410
A	LEU411
A	LEU438

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MLI A 2337

Chain	Residue
A	ARG32
A	LYS33
A	THR38
A	ASP601
A	MET603
A	LEU605
A	ARG833
A	HOH2019

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MLI A 2338

Chain	Residue
A	CYS44
A	GLY48
A	CYS49
A	LEU148
A	ARG433
A	PHE751
A	TYR1236
A	LYS1237
A	ILE1238

---

Functional Information from PROSITE/UniProt

site_id	PS00197
Number of Residues	9
Details	2FE2S_FER_1 2Fe-2S ferredoxin-type iron-sulfur binding region signature. CGGGGCGAC

Chain	Residue	Details
A	CYS44-CYS52

---

site_id	PS00559
Number of Residues	36
Details	MOLYBDOPTERIN_EUK Eukaryotic molybdopterin oxidoreductases signature. AFggKvlktgiiaavta..FaanKHgraVrCvlERgeD

Chain	Residue	Details
A	ALA806-ASP841

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	87
Details	Domain: {"description":"2Fe-2S ferredoxin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00465","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	185
Details	Domain: {"description":"FAD-binding PCMH-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00718","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton acceptor; for azaheterocycle hydroxylase activity","evidences":[{"source":"UniProtKB","id":"O54754","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26322824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UHW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	23
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26322824","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26842593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UHX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EPG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26322824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UHX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26322824","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26842593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EPG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26322824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4UHX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---