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4UGW

Structure of Y357F Bacillus subtilis Nitric Oxide Synthase in complex with 6-(5-((3R,4R)-4-((6-azanyl-4-methyl-pyridin-2-yl)methyl) pyrrolidin-3-yl)oxypentyl)-4-methyl-pyridin-2-amine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004517molecular_functionnitric-oxide synthase activity
A0005575cellular_componentcellular_component
A0006809biological_processnitric oxide biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0020037molecular_functionheme binding
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE HEM A 901
ChainResidue
ATRP60
AH4B902
AHW1904
AHOH2244
AHOH2245
AHOH2246
AHOH2247
AARG65
ACYS66
APHE235
AASN236
ATRP238
AGLU243
ATRP329
ATYR355

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE H4B A 902
ChainResidue
AARG247
ATHR328
ATRP329
APHE342
AHEM901
AHOH2221
AHOH2222
AHOH2229
AHOH2247

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 903
ChainResidue
AGLN129
ATYR239
AASN248

site_idAC4
Number of Residues11
DetailsBINDING SITE FOR RESIDUE HW1 A 904
ChainResidue
AARG65
AHIS128
AILE218
AGLY237
ATRP238
ATYR239
AGLU243
ATRP329
APHE357
AHEM901
AHOH2247

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 905
ChainResidue
AGLY159
AARG161
ATRP238
ASER298
AILE299
AGLN308
AHOH2248

Functional Information from PROSITE/UniProt
site_idPS60001
Number of Residues8
DetailsNOS Nitric oxide synthase (NOS) signature. RCIGRLfW
ChainResidueDetails
AARG65-TRP72

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: axial binding residue
ChainResidueDetails
ACYS66

226707

PDB entries from 2024-10-30

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