4UEZ
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Phe-Y(PO2CH2)-Phe-OH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004181 | molecular_function | metallocarboxypeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0004181 | molecular_function | metallocarboxypeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 420 |
| Chain | Residue |
| A | HIS179 |
| A | GLU182 |
| A | HIS306 |
| A | LFF421 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE LFF A 421 |
| Chain | Residue |
| A | ARG255 |
| A | GLU273 |
| A | HIS306 |
| A | SER307 |
| A | TYR308 |
| A | SER309 |
| A | ILE353 |
| A | ILE357 |
| A | TYR358 |
| A | ALA360 |
| A | SER363 |
| A | THR378 |
| A | GLU380 |
| A | PHE389 |
| A | ZN420 |
| A | HOH2045 |
| B | GLU273 |
| B | LFF421 |
| A | HIS179 |
| A | ARG181 |
| A | GLU182 |
| A | ARG237 |
| A | ASN254 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 420 |
| Chain | Residue |
| B | HIS179 |
| B | GLU182 |
| B | HIS306 |
| B | LFF421 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE LFF B 421 |
| Chain | Residue |
| A | GLU273 |
| A | LFF421 |
| B | HIS179 |
| B | ARG181 |
| B | GLU182 |
| B | ARG237 |
| B | ASN254 |
| B | ARG255 |
| B | THR274 |
| B | HIS306 |
| B | SER307 |
| B | TYR308 |
| B | SER309 |
| B | ILE353 |
| B | ILE357 |
| B | TYR358 |
| B | ALA360 |
| B | SER363 |
| B | THR378 |
| B | GLU380 |
| B | PHE389 |
| B | ZN420 |
| B | HOH2047 |
Functional Information from PROSITE/UniProt
| site_id | PS00132 |
| Number of Residues | 23 |
| Details | CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PaIwIdtGiHSrEwVTQasgvwF |
| Chain | Residue | Details |
| A | PRO170-PHE192 |
| site_id | PS00133 |
| Number of Residues | 11 |
| Details | CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSYSQLLmYPY |
| Chain | Residue | Details |
| A | HIS306-TYR316 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 586 |
| Details | Domain: {"description":"Peptidase M14","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18566513","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V77","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18566513","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V77","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
