4UE8

Complex of D. melanogaster eIF4E with the 4E binding protein Thor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0005737	cellular_component	cytoplasm
A	0006413	biological_process	translational initiation
B	0008190	molecular_function	eukaryotic initiation factor 4E binding
B	0045947	biological_process	negative regulation of translational initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A 1235

Chain	Residue
A	HIS176
A	ASP178

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 1236

Chain	Residue
A	ASN160
A	HOH2112
A	HOH2114

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Functional Information from PROSITE/UniProt

site_id	PS00813
Number of Residues	24
Details	IF4E Eukaryotic initiation factor 4E signature. DYslFKknIrPmWEDaankqGGRW

Chain	Residue	Details
A	ASP123-TRP146

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P06730","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Motif: {"description":"YXXXXLphi motif; atypical","evidences":[{"source":"PubMed","id":"11389445","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"25702871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"25702871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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