4UBH
Resting state of rat cysteine dioxygenase Y157F variant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006534 | biological_process | cysteine metabolic process |
| A | 0007595 | biological_process | lactation |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| A | 0017172 | molecular_function | cysteine dioxygenase activity |
| A | 0019448 | biological_process | L-cysteine catabolic process |
| A | 0033762 | biological_process | response to glucagon |
| A | 0042412 | biological_process | taurine biosynthetic process |
| A | 0043200 | biological_process | response to amino acid |
| A | 0045471 | biological_process | response to ethanol |
| A | 0046439 | biological_process | L-cysteine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051213 | molecular_function | dioxygenase activity |
| A | 0051384 | biological_process | response to glucocorticoid |
| A | 0051591 | biological_process | response to cAMP |
| A | 0097184 | biological_process | response to azide |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue FE2 A 301 |
| Chain | Residue |
| A | HIS86 |
| A | HIS88 |
| A | HIS140 |
| A | CL311 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 302 |
| Chain | Residue |
| A | HIS88 |
| A | ASN134 |
| A | ASP135 |
| A | GLY138 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 303 |
| Chain | Residue |
| A | ASP54 |
| A | ARG57 |
| A | TYR58 |
| A | CYS76 |
| A | PHE53 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 304 |
| Chain | Residue |
| A | THR11 |
| A | LEU12 |
| A | ALA13 |
| A | GLU46 |
| A | HOH553 |
| A | HOH646 |
| A | HOH660 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 305 |
| Chain | Residue |
| A | ASN101 |
| A | ASN144 |
| A | SER146 |
| A | GLU149 |
| A | HOH446 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 306 |
| Chain | Residue |
| A | LYS103 |
| A | THR105 |
| A | ARG141 |
| A | GLU143 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 307 |
| Chain | Residue |
| A | TYR56 |
| A | THR59 |
| A | ARG60 |
| A | THR180 |
| A | HIS182 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 308 |
| Chain | Residue |
| A | TYR50 |
| A | LEU62 |
| A | SER183 |
| A | PHE185 |
| A | GLY186 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 309 |
| Chain | Residue |
| A | LYS8 |
| A | PRO9 |
| A | ARG10 |
| A | TYR40 |
| A | GLU41 |
| A | HOH583 |
| A | HOH738 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 310 |
| Chain | Residue |
| A | ARG57 |
| A | TYR58 |
| A | HIS81 |
| A | GLY82 |
| A | HOH545 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 311 |
| Chain | Residue |
| A | HIS86 |
| A | HIS88 |
| A | HIS140 |
| A | HIS155 |
| A | FE2301 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 312 |
| Chain | Residue |
| A | HIS165 |
| A | HOH524 |
| A | HOH686 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16611640 |
| Chain | Residue | Details |
| A | HIS86 | |
| A | HIS88 | |
| A | HIS140 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CROSSLNK: 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) => ECO:0000269|PubMed:16611640 |
| Chain | Residue | Details |
| A | CYS93 | |
| A | PHE157 |
