4UAX

X-ray crystal structure of ligand free CYP142A2 from Mycobacterium smegmatis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0006629	biological_process	lipid metabolic process
A	0006707	biological_process	cholesterol catabolic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0016042	biological_process	lipid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0036199	molecular_function	cholest-4-en-3-one 26-monooxygenase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue HEM A 501

Chain	Residue
A	GLU56
A	THR238
A	THR241
A	VAL280
A	ARG285
A	ALA335
A	PHE336
A	GLY337
A	PHE338
A	HIS341
A	CYS343
A	MET78
A	GLY345
A	HOH770
A	HOH777
A	ILE79
A	HIS86
A	ARG90
A	PHE97
A	GLY233
A	GLY234
A	THR237

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGTHFCLG

Chain	Residue	Details
A	PHE336-GLY345

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"23489718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25210044","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2YOO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TRI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UAX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---