4U9Z

Structure of the alpha-tubulin acetyltransferase alpha-TAT1/Mec-17 in complex with CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005874	cellular_component	microtubule
A	0019799	molecular_function	tubulin N-acetyltransferase activity
A	0071929	biological_process	alpha-tubulin acetylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue COA A 201

Chain	Residue
A	GLN58
A	ARG137
A	ARG158
A	SER160
A	LYS162
A	LEU163
A	LYS165
A	PHE166
A	LYS169
A	HIS170
A	HOH358
A	PHE124
A	HOH397
A	TYR125
A	ILE126
A	GLN131
A	ARG132
A	HIS133
A	GLY134
A	GLY136

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:23071314, ECO:0000269|PubMed:23071318, ECO:0000269|PubMed:24906155

Chain	Residue	Details
A	PHE124
A	SER160

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Crucial for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:23071318

Chain	Residue	Details
A	GLN58

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000250|UniProtKB:Q8K341, ECO:0000255|HAMAP-Rule:MF_03130

Chain	Residue	Details
A	LYS56
A	LYS146

---