4U9H
Ultra High Resolution Structure Of The Ni-R State Of [Nife]Hydrogenase From Desulufovibrio Vulgaris Miyazaki F
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| L | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| L | 0016151 | molecular_function | nickel cation binding |
| L | 0016491 | molecular_function | oxidoreductase activity |
| L | 0042597 | cellular_component | periplasmic space |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0047806 | molecular_function | cytochrome-c3 hydrogenase activity |
| S | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| S | 0009055 | molecular_function | electron transfer activity |
| S | 0009061 | biological_process | anaerobic respiration |
| S | 0009375 | cellular_component | ferredoxin hydrogenase complex |
| S | 0016020 | cellular_component | membrane |
| S | 0016491 | molecular_function | oxidoreductase activity |
| S | 0042597 | cellular_component | periplasmic space |
| S | 0044569 | cellular_component | [Ni-Fe] hydrogenase complex |
| S | 0046872 | molecular_function | metal ion binding |
| S | 0047806 | molecular_function | cytochrome-c3 hydrogenase activity |
| S | 0051536 | molecular_function | iron-sulfur cluster binding |
| S | 0051538 | molecular_function | 3 iron, 4 sulfur cluster binding |
| S | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 S 1001 |
| Chain | Residue |
| L | HIS235 |
| S | THR113 |
| S | CYS114 |
| S | GLY149 |
| S | CYS150 |
| S | PRO151 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SF4 S 1002 |
| Chain | Residue |
| S | LEU194 |
| S | CYS216 |
| S | LEU217 |
| S | CYS222 |
| S | HIS188 |
| S | CYS191 |
| S | ARG193 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue F3S S 1003 |
| Chain | Residue |
| L | LYS232 |
| L | GLN237 |
| S | THR227 |
| S | ASN229 |
| S | CYS231 |
| S | PHE236 |
| S | TRP241 |
| S | CYS249 |
| S | ILE250 |
| S | CYS252 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MPD S 1004 |
| Chain | Residue |
| L | MPD606 |
| L | HOH996 |
| S | ASN134 |
| S | ASN146 |
| S | HOH1226 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MPD S 1005 |
| Chain | Residue |
| S | ALA211 |
| S | ARG212 |
| S | GLY214 |
| S | ASP244 |
| S | HOH1151 |
| S | HOH1220 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue MPD S 1006 |
| Chain | Residue |
| S | TYR164 |
| S | HOH1179 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue MPD S 1007 |
| Chain | Residue |
| L | ALA169 |
| L | LYS173 |
| L | LEU213 |
| S | HOH1113 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue NWN L 601 |
| Chain | Residue |
| L | ALA477 |
| L | PRO478 |
| L | ARG479 |
| L | LEU482 |
| L | VAL500 |
| L | PRO501 |
| L | SER502 |
| L | CYS546 |
| L | CYS549 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue MG L 602 |
| Chain | Residue |
| L | LEU498 |
| L | HIS552 |
| L | HOH726 |
| L | HOH731 |
| L | HOH737 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue MPD L 603 |
| Chain | Residue |
| L | LYS321 |
| L | MET379 |
| L | HOH908 |
| S | LEU194 |
| S | ASP198 |
| S | HOH1390 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue MPD L 604 |
| Chain | Residue |
| L | PRO359 |
| L | LYS360 |
| L | TYR361 |
| L | HOH955 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue MPD L 605 |
| Chain | Residue |
| L | GLY193 |
| L | GLY194 |
| L | VAL458 |
| L | HOH833 |
| L | HOH1009 |
| L | HOH1068 |
| L | HOH1171 |
| L | HOH1199 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue MPD L 606 |
| Chain | Residue |
| L | ASP166 |
| L | ALA169 |
| L | HOH711 |
| S | LYS143 |
| S | MPD1004 |
| S | HOH1159 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue MPD L 607 |
| Chain | Residue |
| L | TYR307 |
| L | LEU309 |
| L | LYS332 |
| L | PHE474 |
| L | HOH777 |
| L | HOH861 |
| L | HOH994 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue MPD L 608 |
| Chain | Residue |
| L | GLU489 |
| L | GLY494 |
| L | HOH1056 |
| L | HOH1196 |
| S | PHE197 |
| S | PHE202 |
| S | TYR218 |
| S | HOH1413 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue MPD L 609 |
| Chain | Residue |
| L | HOH1065 |
| L | HOH1167 |
| L | GLU348 |
| L | TRP463 |
| L | MET465 |
| L | HOH852 |
| L | HOH912 |
| L | HOH1025 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue MPD L 610 |
| Chain | Residue |
| S | GLU172 |
| S | HOH1105 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue TRS L 611 |
| Chain | Residue |
| L | GLU336 |
| L | ALA349 |
| L | HOH710 |
| L | HOH876 |
| L | HOH947 |
| L | HOH1138 |
| S | PRO263 |
| S | GLN266 |
Functional Information from PROSITE/UniProt
| site_id | PS00507 |
| Number of Residues | 26 |
| Details | NI_HGENASE_L_1 Nickel-dependent hydrogenases large subunit signature 1. RGLEiilkgrdprdaqhftQRtCGVC |
| Chain | Residue | Details |
| L | ARG59-CYS84 |
| site_id | PS00508 |
| Number of Residues | 10 |
| Details | NI_HGENASE_L_2 Nickel-dependent hydrogenases large subunit signature 2. FDPCIACgv.H |
| Chain | Residue | Details |
| L | PHE543-HIS552 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10378274, ECO:0000269|PubMed:9438867, ECO:0007744|PDB:1H2A, ECO:0007744|PDB:1H2R |
| Chain | Residue | Details |
| L | GLU62 | |
| S | CYS249 | |
| S | CYS252 | |
| L | CYS81 | |
| L | CYS84 | |
| L | LEU498 | |
| L | CYS546 | |
| L | CYS549 | |
| L | HIS552 | |
| S | CYS222 | |
| S | CYS231 |
