Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4U8P

Structure of Aspergillus fumigatus UDP-Galactopyranose mutase mutant Y317A complexed with UDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0008767	molecular_function	UDP-galactopyranose mutase activity
A	0016853	molecular_function	isomerase activity
A	0071555	biological_process	cell wall organization
B	0000166	molecular_function	nucleotide binding
B	0008767	molecular_function	UDP-galactopyranose mutase activity
B	0016853	molecular_function	isomerase activity
B	0071555	biological_process	cell wall organization
C	0000166	molecular_function	nucleotide binding
C	0008767	molecular_function	UDP-galactopyranose mutase activity
C	0016853	molecular_function	isomerase activity
C	0071555	biological_process	cell wall organization
D	0000166	molecular_function	nucleotide binding
D	0008767	molecular_function	UDP-galactopyranose mutase activity
D	0016853	molecular_function	isomerase activity
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	binding site for residue FDA A 601

Chain	Residue
A	GLY14
A	VAL60
A	GLY62
A	HIS63
A	VAL64
A	GLY240
A	VAL242
A	GLU373
A	GLY418
A	GLY446
A	ARG447
A	GLY16
A	GLY456
A	ASN457
A	GLN458
A	SER461
A	EDO613
A	HOH723
A	HOH737
A	HOH752
A	HOH768
A	HOH789
A	PRO17
A	HOH946
A	HOH957
A	THR18
A	ASP38
A	SER39
A	GLY45
A	LEU46
A	ALA47

site_id	AC2
Number of Residues	7
Details	binding site for residue UDP A 602

Chain	Residue
A	TYR104
A	MET159
A	TYR162
A	ASN163
A	TRP167
A	TYR453
A	EDO610

site_id	AC3
Number of Residues	8
Details	binding site for residue UDP A 603

Chain	Residue
A	LYS288
A	LEU290
A	PHE291
A	TYR292
A	SER377
A	SER378
A	HOH859
A	HOH861

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 604

Chain	Residue
A	PRO307
A	GLU308
A	ARG309
A	LYS402
A	HOH908

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 A 605

Chain	Residue
A	LYS82
A	GLU83

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 A 606

Chain	Residue
A	LYS70
A	ARG496

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 A 607

Chain	Residue
A	VAL382
A	ASN383
A	GLN384
A	GLU385
A	HOH707
D	LYS199
D	THR200

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 A 608

Chain	Residue
A	LEU351
A	GLN358
A	SER359
A	GLU406
A	HOH917

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 609

Chain	Residue
A	TRP443
A	ASN471
C	GLU494
C	HOH819

site_id	AD1
Number of Residues	6
Details	binding site for residue EDO A 610

Chain	Residue
A	TYR162
A	VAL166
A	ARG327
A	TYR419
A	TYR453
A	UDP602

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO A 611

Chain	Residue
A	ARG303
A	ASP405
A	GLU406

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO A 612

Chain	Residue
A	PHE66
A	SER67
A	THR209
A	HOH757
A	HOH851

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO A 613

Chain	Residue
A	GLY62
A	VAL64
A	TRP315
A	ARG327
A	FDA601
A	HOH956

site_id	AD5
Number of Residues	2
Details	binding site for residue EDO A 614

Chain	Residue
A	ASP485
A	ASN488

site_id	AD6
Number of Residues	33
Details	binding site for residue FDA B 601

Chain	Residue
B	GLY45
B	LEU46
B	ALA47
B	VAL60
B	GLY62
B	HIS63
B	VAL64
B	GLY240
B	VAL242
B	MET269
B	GLU373
B	GLY418
B	TYR419
B	GLY446
B	ARG447
B	GLY456
B	ASN457
B	GLN458
B	SER461
B	EDO615
B	HOH752
B	HOH764
B	HOH771
B	HOH781
B	HOH867
B	HOH908
B	HOH942
B	GLY14
B	GLY16
B	PRO17
B	THR18
B	ASP38
B	SER39

site_id	AD7
Number of Residues	8
Details	binding site for residue UDP B 602

Chain	Residue
B	TYR104
B	MET159
B	TYR162
B	ASN163
B	TRP167
B	TRP178
B	TYR453
B	EDO612

site_id	AD8
Number of Residues	6
Details	binding site for residue UDP B 603

Chain	Residue
B	LYS288
B	LEU290
B	PHE291
B	TYR292
B	SER377
B	SER378

site_id	AD9
Number of Residues	5
Details	binding site for residue SO4 B 604

Chain	Residue
B	PRO307
B	GLU308
B	ARG309
B	LYS402
B	HOH815

site_id	AE1
Number of Residues	2
Details	binding site for residue SO4 B 605

Chain	Residue
B	ASN40
B	ARG413

site_id	AE2
Number of Residues	1
Details	binding site for residue SO4 B 606

Chain	Residue
B	ARG496

site_id	AE3
Number of Residues	2
Details	binding site for residue SO4 B 607

Chain	Residue
B	LYS82
B	GLU83

site_id	AE4
Number of Residues	6
Details	binding site for residue SO4 B 608

Chain	Residue
B	PRO114
B	LYS115
B	ASN383
B	THR386
B	HOH701
B	HOH703

site_id	AE5
Number of Residues	7
Details	binding site for residue EDO B 609

Chain	Residue
B	PRO114
B	GLU116
B	PRO324
B	ASP390
B	EDO610
B	EDO613
B	HOH712

site_id	AE6
Number of Residues	5
Details	binding site for residue EDO B 610

Chain	Residue
B	ASN322
B	CYS323
B	ASP390
B	EDO609
B	HOH707

site_id	AE7
Number of Residues	4
Details	binding site for residue EDO B 611

Chain	Residue
B	ASN471
B	HOH1012
D	GLU494
D	HOH935

site_id	AE8
Number of Residues	6
Details	binding site for residue EDO B 612

Chain	Residue
B	TYR162
B	VAL166
B	ARG327
B	TYR419
B	TYR453
B	UDP602

site_id	AE9
Number of Residues	7
Details	binding site for residue EDO B 613

Chain	Residue
B	GLU116
B	GLU117
B	ASP321
B	CYS323
B	PRO324
B	EDO609
B	HOH731

site_id	AF1
Number of Residues	5
Details	binding site for residue EDO B 614

Chain	Residue
B	PHE66
B	SER67
B	THR209
B	HOH763
B	HOH936

site_id	AF2
Number of Residues	5
Details	binding site for residue EDO B 615

Chain	Residue
B	GLY62
B	TRP315
B	ARG327
B	FDA601
B	HOH866

site_id	AF3
Number of Residues	6
Details	binding site for residue EDO B 616

Chain	Residue
B	LEU179
B	GLY180
B	PRO484
B	ASP485
B	ASN488
B	HOH877

site_id	AF4
Number of Residues	35
Details	binding site for residue FDA C 601

Chain	Residue
C	GLY14
C	GLY16
C	PRO17
C	THR18
C	ASP38
C	SER39
C	GLY45
C	LEU46
C	ALA47
C	VAL60
C	GLY62
C	HIS63
C	VAL64
C	GLY240
C	VAL242
C	MET269
C	THR295
C	GLU373
C	GLY418
C	TYR419
C	GLY446
C	ARG447
C	GLY456
C	ASN457
C	GLN458
C	SER461
C	EDO610
C	EDO613
C	HOH734
C	HOH807
C	HOH812
C	HOH850
C	HOH859
C	HOH878
C	HOH894

site_id	AF5
Number of Residues	10
Details	binding site for residue UDP C 602

Chain	Residue
C	ARG91
C	TYR104
C	MET159
C	TYR162
C	ASN163
C	TRP167
C	TRP178
C	TYR453
C	EDO609
C	EDO610

site_id	AF6
Number of Residues	6
Details	binding site for residue UDP C 603

Chain	Residue
C	LYS288
C	LEU290
C	PHE291
C	TYR292
C	SER377
C	SER378

site_id	AF7
Number of Residues	6
Details	binding site for residue SO4 C 604

Chain	Residue
C	PRO307
C	GLU308
C	ARG309
C	LYS402
C	HOH911
C	HOH947

site_id	AF8
Number of Residues	2
Details	binding site for residue SO4 C 605

Chain	Residue
C	THR152
C	ARG160

site_id	AF9
Number of Residues	2
Details	binding site for residue SO4 C 606

Chain	Residue
C	PRO114
C	LYS115

site_id	AG1
Number of Residues	3
Details	binding site for residue SO4 C 607

Chain	Residue
B	ASN248
C	LYS70
C	ARG496

site_id	AG2
Number of Residues	4
Details	binding site for residue EDO C 608

Chain	Residue
A	GLU494
C	ASN471
C	HOH817
C	HOH980

site_id	AG3
Number of Residues	6
Details	binding site for residue EDO C 609

Chain	Residue
C	TYR162
C	VAL166
C	ARG327
C	TYR419
C	TYR453
C	UDP602

site_id	AG4
Number of Residues	5
Details	binding site for residue EDO C 610

Chain	Residue
C	VAL64
C	ARG91
C	FDA601
C	UDP602
C	EDO613

site_id	AG5
Number of Residues	4
Details	binding site for residue EDO C 611

Chain	Residue
C	ARG303
C	GLY304
C	ASP405
C	GLU406

site_id	AG6
Number of Residues	5
Details	binding site for residue EDO C 612

Chain	Residue
C	PHE66
C	SER67
C	THR209
C	HOH763
C	HOH818

site_id	AG7
Number of Residues	6
Details	binding site for residue EDO C 613

Chain	Residue
C	GLY62
C	TRP315
C	ARG327
C	FDA601
C	EDO610
C	HOH737

site_id	AG8
Number of Residues	4
Details	binding site for residue EDO C 614

Chain	Residue
C	MET149
C	ALA185
C	ASN187
C	HOH757

site_id	AG9
Number of Residues	2
Details	binding site for residue EDO C 615

Chain	Residue
C	GLY202
C	TRP204

site_id	AH1
Number of Residues	7
Details	binding site for residue EDO C 616

Chain	Residue
C	TRP178
C	LEU179
C	GLY180
C	PRO484
C	ASP485
C	ASN488
C	HOH822

site_id	AH2
Number of Residues	32
Details	binding site for residue FDA D 601

Chain	Residue
D	GLY14
D	GLY16
D	PRO17
D	THR18
D	ASP38
D	SER39
D	GLY45
D	LEU46
D	ALA47
D	VAL60
D	GLY62
D	HIS63
D	VAL64
D	GLY240
D	VAL242
D	MET269
D	GLU373
D	GLY418
D	TYR419
D	GLY446
D	ARG447
D	GLY456
D	ASN457
D	GLN458
D	SER461
D	EDO609
D	HOH728
D	HOH753
D	HOH798
D	HOH814
D	HOH872
D	HOH891

site_id	AH3
Number of Residues	8
Details	binding site for residue UDP D 602

Chain	Residue
D	TYR104
D	MET159
D	TYR162
D	ASN163
D	TRP167
D	TRP178
D	TYR453
D	EDO608

site_id	AH4
Number of Residues	5
Details	binding site for residue SO4 D 603

Chain	Residue
D	PRO307
D	GLU308
D	ARG309
D	LYS402
D	HOH904

site_id	AH5
Number of Residues	2
Details	binding site for residue SO4 D 604

Chain	Residue
D	LYS115
D	HOH980

site_id	AH6
Number of Residues	3
Details	binding site for residue SO4 D 605

Chain	Residue
D	THR152
D	ARG160
D	HOH845

site_id	AH7
Number of Residues	5
Details	binding site for residue SO4 D 606

Chain	Residue
A	ASN279
A	ASP280
A	GLN281
A	GLU282
D	LYS70

site_id	AH8
Number of Residues	5
Details	binding site for residue EDO D 607

Chain	Residue
B	GLU494
B	HOH874
D	TRP443
D	ASN471
D	HOH880

site_id	AH9
Number of Residues	6
Details	binding site for residue EDO D 608

Chain	Residue
D	TYR162
D	VAL166
D	ARG327
D	TYR419
D	TYR453
D	UDP602

site_id	AI1
Number of Residues	6
Details	binding site for residue EDO D 609

Chain	Residue
D	GLY62
D	VAL64
D	TRP315
D	ARG327
D	FDA601
D	HOH854

site_id	AI2
Number of Residues	4
Details	binding site for residue EDO D 610

Chain	Residue
D	MET149
D	ALA185
D	ASN187
D	HOH764

site_id	AI3
Number of Residues	7
Details	binding site for residue EDO D 611

Chain	Residue
D	TRP178
D	LEU179
D	GLY180
D	PRO484
D	ASP485
D	ASN488
D	HOH825

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22294687","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22334662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UKA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UKH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UKK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UKL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UTE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22334662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UKP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22334662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UKF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UKQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23036087","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VWT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22294687","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22334662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UKF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UKH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UTH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22334662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UKH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UKP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22294687","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22334662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UKH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UTH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22294687","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22334662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UKF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UKH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UTH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22334662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UKH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)