Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4U8D

X-ray structure of Mg-bound human sorcin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002020	molecular_function	protease binding
A	0005102	molecular_function	signaling receptor binding
A	0005246	molecular_function	calcium channel regulator activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0010459	biological_process	negative regulation of heart rate
A	0010468	biological_process	regulation of gene expression
A	0010649	biological_process	regulation of cell communication by electrical coupling
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0030018	cellular_component	Z disc
A	0030315	cellular_component	T-tubule
A	0031982	cellular_component	vesicle
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0042584	cellular_component	chromaffin granule membrane
A	0044325	molecular_function	transmembrane transporter binding
A	0046872	molecular_function	metal ion binding
A	0046982	molecular_function	protein heterodimerization activity
A	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
A	0051924	biological_process	regulation of calcium ion transport
A	0055118	biological_process	negative regulation of cardiac muscle contraction
A	0061178	biological_process	regulation of insulin secretion involved in cellular response to glucose stimulus
A	0070062	cellular_component	extracellular exosome
A	0086004	biological_process	regulation of cardiac muscle cell contraction
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0140311	molecular_function	protein sequestering activity
A	0140416	molecular_function	transcription regulator inhibitor activity
A	1901077	biological_process	regulation of relaxation of muscle
A	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
B	0002020	molecular_function	protease binding
B	0005102	molecular_function	signaling receptor binding
B	0005246	molecular_function	calcium channel regulator activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0010459	biological_process	negative regulation of heart rate
B	0010468	biological_process	regulation of gene expression
B	0010649	biological_process	regulation of cell communication by electrical coupling
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0016020	cellular_component	membrane
B	0016529	cellular_component	sarcoplasmic reticulum
B	0030018	cellular_component	Z disc
B	0030315	cellular_component	T-tubule
B	0031982	cellular_component	vesicle
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0042584	cellular_component	chromaffin granule membrane
B	0044325	molecular_function	transmembrane transporter binding
B	0046872	molecular_function	metal ion binding
B	0046982	molecular_function	protein heterodimerization activity
B	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
B	0051924	biological_process	regulation of calcium ion transport
B	0055118	biological_process	negative regulation of cardiac muscle contraction
B	0061178	biological_process	regulation of insulin secretion involved in cellular response to glucose stimulus
B	0070062	cellular_component	extracellular exosome
B	0086004	biological_process	regulation of cardiac muscle cell contraction
B	0140297	molecular_function	DNA-binding transcription factor binding
B	0140311	molecular_function	protein sequestering activity
B	0140416	molecular_function	transcription regulator inhibitor activity
B	1901077	biological_process	regulation of relaxation of muscle
B	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 201

Chain	Residue
A	ASP83
A	ASP85
A	SER87
A	THR89
A	HOH343
A	HOH353

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 202

Chain	Residue
A	THR119
A	HOH366
A	ASP113
A	ASP115
A	SER117

site_id	AC3
Number of Residues	6
Details	binding site for residue MG B 201

Chain	Residue
B	ASP83
B	ASP85
B	SER87
B	THR89
B	HOH333
B	HOH341

site_id	AC4
Number of Residues	5
Details	binding site for residue MG B 202

Chain	Residue
B	GLN32
B	ASP33
B	TYR36
B	GLY37
B	SER61

site_id	AC5
Number of Residues	5
Details	binding site for residue MG B 203

Chain	Residue
A	HOH331
B	THR31
B	GLN32
B	TRP99
B	ASN103

site_id	AC6
Number of Residues	5
Details	binding site for residue MG B 204

Chain	Residue
B	HOH360
B	HOH361
B	HOH362
B	HOH363
B	HOH364

site_id	AC7
Number of Residues	2
Details	binding site for residue MG B 205

Chain	Residue
B	ASP50
B	ASP52

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DRDMSGTMGfnEF

Chain	Residue	Details
A	ASP83-PHE95
A	ASP113-LEU125

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	66
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	70
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	70
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)