4U89

4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
A	0009237	biological_process	siderophore metabolic process
A	0009239	biological_process	enterobactin biosynthetic process
A	0009366	cellular_component	enterobactin synthetase complex
A	0016740	molecular_function	transferase activity
A	0016780	molecular_function	phosphotransferase activity, for other substituted phosphate groups
A	0019290	biological_process	siderophore biosynthetic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	34
Details	binding site for residue COA A 301

Chain	Residue
A	ARG48
A	THR92
A	HIS93
A	ASP114
A	ASN123
A	GLY124
A	LYS156
A	GLU157
A	TYR160
A	LYS161
A	PHE164
A	PHE52
A	TRP170
A	LEU171
A	GLY172
A	PHE173
A	HOH401
A	HOH438
A	HOH443
A	HOH467
A	HOH491
A	HOH493
A	ARG56
A	HOH503
A	HOH509
A	HOH510
A	HOH515
A	HOH523
A	LYS75
A	LYS78
A	GLY79
A	GLU80
A	PRO81
A	LEU91

---

site_id	AC2
Number of Residues	5
Details	binding site for residue NA A 302

Chain	Residue
A	ASP137
A	THR141
A	THR179
A	PHE180
A	HOH513

---

site_id	AC3
Number of Residues	4
Details	binding site for residue NA A 303

Chain	Residue
A	HIS177
A	THR179
A	VAL192
A	HOH431

---

site_id	AC4
Number of Residues	5
Details	binding site for residue NA A 304

Chain	Residue
A	PRO72
A	LEU74
A	CYS82
A	HOH540
A	HOH616

---

site_id	AC5
Number of Residues	4
Details	binding site for residue NA A 305

Chain	Residue
A	TYR25
A	HOH543
A	HOH650
A	HOH666

---

site_id	AC6
Number of Residues	4
Details	binding site for residue NA A 306

Chain	Residue
A	CYS94
A	ALA95
A	HOH486
A	HOH487

---

site_id	AC7
Number of Residues	4
Details	binding site for residue NA A 307

Chain	Residue
A	HOH417
A	HOH534
A	HOH556
A	HOH571

---

site_id	AC8
Number of Residues	6
Details	binding site for residue NA A 308

Chain	Residue
A	TRP83
A	GLY89
A	PRO165
A	HOH500
A	HOH507
A	HOH663

---

site_id	AC9
Number of Residues	2
Details	binding site for residue NA A 309

Chain	Residue
A	PRO143
A	PG4314

---

site_id	AD1
Number of Residues	4
Details	binding site for residue NA A 310

Chain	Residue
A	PRO35
A	HOH403
A	HOH456
A	HOH484

---

site_id	AD2
Number of Residues	5
Details	binding site for residue NA A 311

Chain	Residue
A	GLU17
A	PRO33
A	PRO35
A	HOH435
A	HOH444

---

site_id	AD3
Number of Residues	3
Details	binding site for residue NA A 312

Chain	Residue
A	HOH419
A	HOH519
A	HOH539

---

site_id	AD4
Number of Residues	7
Details	binding site for residue PO4 A 313

Chain	Residue
A	SER44
A	ARG48
A	HOH464
A	HOH512
A	HOH532
A	HOH561
A	HOH619

---

site_id	AD5
Number of Residues	8
Details	binding site for residue PG4 A 314

Chain	Residue
A	ALA42
A	ARG49
A	ARG140
A	MET142
A	ASP183
A	SER184
A	GLY186
A	NA309

---

site_id	AD6
Number of Residues	1
Details	binding site for residue IMD A 315

Chain	Residue
A	TRP170

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:24963544, ECO:0000269|PubMed:25450595, ECO:0000269|Ref.11

Chain	Residue	Details
A	ARG48
A	ARG56
A	LYS75
A	THR92
A	LYS161
A	LEU171

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:25450595, ECO:0007744|PDB:4QVH

Chain	Residue	Details
A	ASP114
A	ALA115
A	GLU116

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:24963544, ECO:0000269|Ref.11

Chain	Residue	Details
A	GLU157

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