4U7A

The carboxy-terminal domain of Erb1 is a seven-bladed beta-propeller that binds RNA.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A	0003674	molecular_function	molecular_function
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0006364	biological_process	rRNA processing
A	0030687	cellular_component	preribosome, large subunit precursor
A	0042254	biological_process	ribosome biogenesis
A	0042273	biological_process	ribosomal large subunit biogenesis
A	0043021	molecular_function	ribonucleoprotein complex binding
A	0070180	molecular_function	large ribosomal subunit rRNA binding
A	0070545	cellular_component	PeBoW complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue EDO A 901

Chain	Residue
A	ASP446
A	PRO447
A	ASN498
A	ASN499
A	GLY500
A	PHE518
A	ILE522
A	HOH1093
A	HOH1153

---

site_id	AC2
Number of Residues	7
Details	binding site for residue EDO A 902

Chain	Residue
A	ILE432
A	VAL472
A	ILE517
A	GLY772
A	ARG803
A	HOH1036
A	HOH1058

---

site_id	AC3
Number of Residues	9
Details	binding site for residue GOL A 903

Chain	Residue
A	LYS639
A	GLY640
A	ILE641
A	SER658
A	GLN659
A	ARG660
A	TYR661
A	ARG663
A	HOH1201

---

site_id	AC4
Number of Residues	1
Details	binding site for residue EOH A 904

Chain	Residue
A	TYR608

---

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATGsdDgTVRVWEI

Chain	Residue	Details
A	LEU452-ILE466

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	39
Details	Repeat: {"description":"WD 1","evidences":[{"source":"HAMAP-Rule","id":"MF_03027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	Repeat: {"description":"WD 2","evidences":[{"source":"HAMAP-Rule","id":"MF_03027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	42
Details	Repeat: {"description":"WD 3","evidences":[{"source":"HAMAP-Rule","id":"MF_03027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	38
Details	Repeat: {"description":"WD 4","evidences":[{"source":"HAMAP-Rule","id":"MF_03027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	39
Details	Repeat: {"description":"WD 5","evidences":[{"source":"HAMAP-Rule","id":"MF_03027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	39
Details	Repeat: {"description":"WD 6","evidences":[{"source":"HAMAP-Rule","id":"MF_03027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	31
Details	Repeat: {"description":"WD 7","evidences":[{"source":"HAMAP-Rule","id":"MF_03027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---