4U7A
The carboxy-terminal domain of Erb1 is a seven-bladed beta-propeller that binds RNA.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000463 | biological_process | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| A | 0000466 | biological_process | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| A | 0003674 | molecular_function | molecular_function |
| A | 0003677 | molecular_function | DNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0006364 | biological_process | rRNA processing |
| A | 0030687 | cellular_component | preribosome, large subunit precursor |
| A | 0042254 | biological_process | ribosome biogenesis |
| A | 0042273 | biological_process | ribosomal large subunit biogenesis |
| A | 0043021 | molecular_function | ribonucleoprotein complex binding |
| A | 0070180 | molecular_function | large ribosomal subunit rRNA binding |
| A | 0070545 | cellular_component | PeBoW complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 901 |
| Chain | Residue |
| A | ASP446 |
| A | PRO447 |
| A | ASN498 |
| A | ASN499 |
| A | GLY500 |
| A | PHE518 |
| A | ILE522 |
| A | HOH1093 |
| A | HOH1153 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 902 |
| Chain | Residue |
| A | ILE432 |
| A | VAL472 |
| A | ILE517 |
| A | GLY772 |
| A | ARG803 |
| A | HOH1036 |
| A | HOH1058 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 903 |
| Chain | Residue |
| A | LYS639 |
| A | GLY640 |
| A | ILE641 |
| A | SER658 |
| A | GLN659 |
| A | ARG660 |
| A | TYR661 |
| A | ARG663 |
| A | HOH1201 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue EOH A 904 |
| Chain | Residue |
| A | TYR608 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATGsdDgTVRVWEI |
| Chain | Residue | Details |
| A | LEU452-ILE466 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956 |
| Chain | Residue | Details |
| A | SER23 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358 |
| Chain | Residue | Details |
| A | SER72 | |
| A | SER76 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956 |
| Chain | Residue | Details |
| A | SER146 | |
| A | SER149 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956 |
| Chain | Residue | Details |
| A | SER418 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| A | LYS127 |
