Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003714 | molecular_function | transcription corepressor activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | SER100 |
| A | PRO205 |
| A | TYR206 |
| A | HIS236 |
| A | CYS237 |
| A | GLY238 |
| A | ASN240 |
| A | ASN243 |
| A | THR264 |
| A | ALA265 |
| A | ARG266 |
| A | GLY101 |
| A | ASP290 |
| A | VAL291 |
| A | HIS315 |
| A | TRP318 |
| A | PPY402 |
| A | HOH548 |
| A | HOH599 |
| A | HOH600 |
| A | HOH608 |
| A | HOH627 |
| A | THR128 |
| A | HOH631 |
| A | HOH652 |
| A | HOH672 |
| A | GLY181 |
| A | GLY183 |
| A | ARG184 |
| A | VAL185 |
| A | TYR203 |
| A | ASP204 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue PPY A 402 |
| Chain | Residue |
| A | TYR76 |
| A | HIS77 |
| A | ARG97 |
| A | ILE98 |
| A | GLY99 |
| A | SER100 |
| A | GLY101 |
| A | ARG266 |
| A | HIS315 |
| A | TRP318 |
| A | MET327 |
| A | NAD401 |
| A | HOH597 |
| A | HOH632 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 403 |
| Chain | Residue |
| A | FMT404 |
| A | HOH637 |
| A | HOH638 |
| A | HOH681 |
| A | HOH682 |
| A | HOH684 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 404 |
| Chain | Residue |
| A | GLU175 |
| A | ASP231 |
| A | GLY258 |
| A | ARG285 |
| A | CA403 |
Functional Information from PROSITE/UniProt
| site_id | PS00065 |
| Number of Residues | 28 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. LGIIGlGRVGqavalrakafgfn.VLfYD |
| Chain | Residue | Details |
| A | LEU177-ASP204 | |
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MRqGaFLVNtARGgLVD |
| Chain | Residue | Details |
| A | MET255-ASP271 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
