4U6A
X-ray crystal structure of human TNKS in complex with a small molecule inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003950 | molecular_function | NAD+ poly-ADP-ribosyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 1401 |
Chain | Residue |
A | CYS1234 |
A | HIS1237 |
A | CYS1242 |
A | CYS1245 |
site_id | AC2 |
Number of Residues | 11 |
Details | binding site for residue 3DN A 1402 |
Chain | Residue |
A | TYR1213 |
A | LYS1220 |
A | SER1221 |
A | TYR1224 |
A | ILE1228 |
A | GOL1405 |
A | HIS1184 |
A | GLY1185 |
A | PHE1188 |
A | ALA1202 |
A | TYR1203 |
site_id | AC3 |
Number of Residues | 12 |
Details | binding site for residue GOL A 1403 |
Chain | Residue |
A | ARG1165 |
A | GLU1199 |
A | ARG1200 |
A | HIS1270 |
A | ALA1271 |
A | HIS1276 |
A | TYR1295 |
A | ARG1296 |
A | GLN1299 |
A | GOL1407 |
A | GOL1407 |
A | HOH1501 |
site_id | AC4 |
Number of Residues | 9 |
Details | binding site for residue GOL A 1404 |
Chain | Residue |
A | HIS1184 |
A | SER1186 |
A | ILE1192 |
A | PHE1197 |
A | ASP1198 |
A | HIS1201 |
A | ILE1212 |
A | HOH1545 |
A | HOH1565 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue GOL A 1405 |
Chain | Residue |
A | TYR1203 |
A | ILE1204 |
A | GLY1205 |
A | ILE1228 |
A | 3DN1402 |
A | HOH1546 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue EDO A 1406 |
Chain | Residue |
A | PRO1273 |
A | HIS1275 |
site_id | AC7 |
Number of Residues | 10 |
Details | binding site for residue GOL A 1407 |
Chain | Residue |
A | GLU1199 |
A | GLU1199 |
A | HIS1270 |
A | HIS1270 |
A | TYR1295 |
A | TYR1295 |
A | ARG1296 |
A | ARG1296 |
A | GOL1403 |
A | GOL1403 |
site_id | AC8 |
Number of Residues | 8 |
Details | binding site for residue EDO A 1408 |
Chain | Residue |
A | HIS1164 |
A | HIS1164 |
A | ARG1165 |
A | GLU1168 |
A | GLU1168 |
A | GLU1298 |
A | GLU1298 |
A | HOH1504 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue GOL A 1409 |
Chain | Residue |
A | LYS1152 |
A | LYS1152 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"18436240","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2RF5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UDD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DVI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LI6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LI8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N3R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W6E","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |