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4U6A

X-ray crystal structure of human TNKS in complex with a small molecule inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003950molecular_functionNAD+ poly-ADP-ribosyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 1401
ChainResidue
ACYS1234
AHIS1237
ACYS1242
ACYS1245

site_idAC2
Number of Residues11
Detailsbinding site for residue 3DN A 1402
ChainResidue
ATYR1213
ALYS1220
ASER1221
ATYR1224
AILE1228
AGOL1405
AHIS1184
AGLY1185
APHE1188
AALA1202
ATYR1203

site_idAC3
Number of Residues12
Detailsbinding site for residue GOL A 1403
ChainResidue
AARG1165
AGLU1199
AARG1200
AHIS1270
AALA1271
AHIS1276
ATYR1295
AARG1296
AGLN1299
AGOL1407
AGOL1407
AHOH1501

site_idAC4
Number of Residues9
Detailsbinding site for residue GOL A 1404
ChainResidue
AHIS1184
ASER1186
AILE1192
APHE1197
AASP1198
AHIS1201
AILE1212
AHOH1545
AHOH1565

site_idAC5
Number of Residues6
Detailsbinding site for residue GOL A 1405
ChainResidue
ATYR1203
AILE1204
AGLY1205
AILE1228
A3DN1402
AHOH1546

site_idAC6
Number of Residues2
Detailsbinding site for residue EDO A 1406
ChainResidue
APRO1273
AHIS1275

site_idAC7
Number of Residues10
Detailsbinding site for residue GOL A 1407
ChainResidue
AGLU1199
AGLU1199
AHIS1270
AHIS1270
ATYR1295
ATYR1295
AARG1296
AARG1296
AGOL1403
AGOL1403

site_idAC8
Number of Residues8
Detailsbinding site for residue EDO A 1408
ChainResidue
AHIS1164
AHIS1164
AARG1165
AGLU1168
AGLU1168
AGLU1298
AGLU1298
AHOH1504

site_idAC9
Number of Residues2
Detailsbinding site for residue GOL A 1409
ChainResidue
ALYS1152
ALYS1152

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18436240","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2RF5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UDD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DVI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LI6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LI8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N3R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W6E","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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