4U4T
Structure of a nitrate/nitrite antiporter NarK in nitrate-bound inward-open state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005452 | molecular_function | solute:inorganic anion antiporter activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015112 | molecular_function | nitrate transmembrane transporter activity |
| A | 0015113 | molecular_function | nitrite transmembrane transporter activity |
| A | 0015291 | molecular_function | secondary active transmembrane transporter activity |
| A | 0015706 | biological_process | nitrate transmembrane transport |
| A | 0015707 | biological_process | nitrite transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042128 | biological_process | nitrate assimilation |
| A | 0043602 | biological_process | nitrate catabolic process |
| A | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue NO3 A 501 |
| Chain | Residue |
| A | ARG89 |
| A | PHE147 |
| A | ASN175 |
| A | TYR263 |
| A | PHE267 |
| A | ARG305 |
| A | SER411 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 502 |
| Chain | Residue |
| A | HOH615 |
| A | HOH620 |
| A | HIS255 |
| A | HIS460 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue OLA A 503 |
| Chain | Residue |
| A | PHE197 |
| A | TRP217 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue OLA A 504 |
| Chain | Residue |
| A | SER269 |
| A | PHE420 |
| A | PHE442 |
| A | PHE445 |
| A | TYR446 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 505 |
| Chain | Residue |
| A | VAL117 |
| A | TRP118 |
| A | PHE121 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue OLC A 506 |
| Chain | Residue |
| A | SER190 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue OLC A 507 |
| Chain | Residue |
| A | MET76 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 508 |
| Chain | Residue |
| A | MET76 |
| A | PHE419 |
| A | LYS423 |
| A | SER427 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue OLC A 509 |
| Chain | Residue |
| A | TRP231 |
| A | LYS440 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 262 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"25959928","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U4T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U4V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 63 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"25959928","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U4T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U4V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 54 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25959928","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U4T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U4V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25959928","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U4T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U4V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23665960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4JRE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25959928","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U4T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U4W","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25959928","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U4T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for activity","evidences":[{"source":"PubMed","id":"23665960","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25959928","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
