Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4U0H

Crystal Structure of M. tuberculosis ClpP1P1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008236	molecular_function	serine-type peptidase activity
A	0009368	cellular_component	endopeptidase Clp complex
A	0051117	molecular_function	ATPase binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008236	molecular_function	serine-type peptidase activity
B	0009368	cellular_component	endopeptidase Clp complex
B	0051117	molecular_function	ATPase binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008236	molecular_function	serine-type peptidase activity
C	0009368	cellular_component	endopeptidase Clp complex
C	0051117	molecular_function	ATPase binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008236	molecular_function	serine-type peptidase activity
D	0009368	cellular_component	endopeptidase Clp complex
D	0051117	molecular_function	ATPase binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008236	molecular_function	serine-type peptidase activity
E	0009368	cellular_component	endopeptidase Clp complex
E	0051117	molecular_function	ATPase binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008236	molecular_function	serine-type peptidase activity
F	0009368	cellular_component	endopeptidase Clp complex
F	0051117	molecular_function	ATPase binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008236	molecular_function	serine-type peptidase activity
G	0009368	cellular_component	endopeptidase Clp complex
G	0051117	molecular_function	ATPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 301

Chain	Residue
A	SER70
A	ILE71
A	SER72

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 302

Chain	Residue
A	ARG171
A	ARG173

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 C 301

Chain	Residue
C	PHE143
C	SER70
C	ILE71
C	SER72
C	GLY127

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 C 302

Chain	Residue
C	ARG171
C	ARG173
C	TRP174

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 D 301

Chain	Residue
D	SER70
D	ILE71
D	SER72
D	GLY127
D	PHE143

site_id	AC6
Number of Residues	1
Details	binding site for residue SO4 D 302

Chain	Residue
D	ARG164

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 D 303

Chain	Residue
D	ARG171
D	ARG173

site_id	AC8
Number of Residues	1
Details	binding site for residue SO4 D 304

Chain	Residue
D	ARG173

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 E 301

Chain	Residue
E	SER70
E	SER72
E	GLY127
E	PHE143

site_id	AD1
Number of Residues	2
Details	binding site for residue SO4 E 302

Chain	Residue
E	ARG171
E	ARG173

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 E 303

Chain	Residue
E	ARG164
E	ARG173
E	GLU182
E	TYR183

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 G 301

Chain	Residue
G	SER70
G	ILE71
G	SER72
G	PHE143

site_id	AD4
Number of Residues	2
Details	binding site for residue SO4 G 302

Chain	Residue
G	ARG171
G	ARG173

site_id	AD5
Number of Residues	3
Details	binding site for residue SO4 G 303

Chain	Residue
G	GLN160
G	ARG164
G	ARG173

Functional Information from PROSITE/UniProt

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RyalPharILMHQP

Chain	Residue	Details
A	ARG112-PRO125

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
A	SER98
B	SER98
C	SER98
D	SER98
E	SER98
F	SER98
G	SER98

site_id	SWS_FT_FI2
Number of Residues	7
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
A	HIS123
B	HIS123
C	HIS123
D	HIS123
E	HIS123
F	HIS123
G	HIS123

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)