Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4U0G

Crystal Structure of M. tuberculosis ClpP1P2 bound to ADEP and agonist

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0004176	molecular_function	ATP-dependent peptidase activity
a	0004252	molecular_function	serine-type endopeptidase activity
a	0005737	cellular_component	cytoplasm
a	0005886	cellular_component	plasma membrane
a	0006508	biological_process	proteolysis
a	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
a	0051117	molecular_function	ATPase binding
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0051117	molecular_function	ATPase binding
b	0004176	molecular_function	ATP-dependent peptidase activity
b	0004252	molecular_function	serine-type endopeptidase activity
b	0005737	cellular_component	cytoplasm
b	0005886	cellular_component	plasma membrane
b	0006508	biological_process	proteolysis
b	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
b	0051117	molecular_function	ATPase binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0051117	molecular_function	ATPase binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0051117	molecular_function	ATPase binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0051117	molecular_function	ATPase binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0051117	molecular_function	ATPase binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0051117	molecular_function	ATPase binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005886	cellular_component	plasma membrane
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0051117	molecular_function	ATPase binding
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0005886	cellular_component	plasma membrane
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0051117	molecular_function	ATPase binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0005886	cellular_component	plasma membrane
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0051117	molecular_function	ATPase binding
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0005886	cellular_component	plasma membrane
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0051117	molecular_function	ATPase binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0005886	cellular_component	plasma membrane
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0051117	molecular_function	ATPase binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0005886	cellular_component	plasma membrane
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0051117	molecular_function	ATPase binding
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0005886	cellular_component	plasma membrane
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0051117	molecular_function	ATPase binding
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0005886	cellular_component	plasma membrane
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0051117	molecular_function	ATPase binding
O	0004176	molecular_function	ATP-dependent peptidase activity
O	0004252	molecular_function	serine-type endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005886	cellular_component	plasma membrane
O	0006508	biological_process	proteolysis
O	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
O	0051117	molecular_function	ATPase binding
P	0004176	molecular_function	ATP-dependent peptidase activity
P	0004252	molecular_function	serine-type endopeptidase activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005886	cellular_component	plasma membrane
P	0006508	biological_process	proteolysis
P	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
P	0051117	molecular_function	ATPase binding
Q	0004176	molecular_function	ATP-dependent peptidase activity
Q	0004252	molecular_function	serine-type endopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005886	cellular_component	plasma membrane
Q	0006508	biological_process	proteolysis
Q	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
Q	0051117	molecular_function	ATPase binding
R	0004176	molecular_function	ATP-dependent peptidase activity
R	0004252	molecular_function	serine-type endopeptidase activity
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0005886	cellular_component	plasma membrane
R	0006508	biological_process	proteolysis
R	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
R	0051117	molecular_function	ATPase binding
S	0004176	molecular_function	ATP-dependent peptidase activity
S	0004252	molecular_function	serine-type endopeptidase activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005886	cellular_component	plasma membrane
S	0006508	biological_process	proteolysis
S	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
S	0051117	molecular_function	ATPase binding
T	0004176	molecular_function	ATP-dependent peptidase activity
T	0004252	molecular_function	serine-type endopeptidase activity
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0005886	cellular_component	plasma membrane
T	0006508	biological_process	proteolysis
T	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
T	0051117	molecular_function	ATPase binding
U	0004176	molecular_function	ATP-dependent peptidase activity
U	0004252	molecular_function	serine-type endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005886	cellular_component	plasma membrane
U	0006508	biological_process	proteolysis
U	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
U	0051117	molecular_function	ATPase binding
V	0004176	molecular_function	ATP-dependent peptidase activity
V	0004252	molecular_function	serine-type endopeptidase activity
V	0005737	cellular_component	cytoplasm
V	0005886	cellular_component	plasma membrane
V	0006508	biological_process	proteolysis
V	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
V	0051117	molecular_function	ATPase binding
W	0004176	molecular_function	ATP-dependent peptidase activity
W	0004252	molecular_function	serine-type endopeptidase activity
W	0005737	cellular_component	cytoplasm
W	0005886	cellular_component	plasma membrane
W	0006508	biological_process	proteolysis
W	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
W	0051117	molecular_function	ATPase binding
X	0004176	molecular_function	ATP-dependent peptidase activity
X	0004252	molecular_function	serine-type endopeptidase activity
X	0005737	cellular_component	cytoplasm
X	0005886	cellular_component	plasma membrane
X	0006508	biological_process	proteolysis
X	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
X	0051117	molecular_function	ATPase binding
Y	0004176	molecular_function	ATP-dependent peptidase activity
Y	0004252	molecular_function	serine-type endopeptidase activity
Y	0005737	cellular_component	cytoplasm
Y	0005886	cellular_component	plasma membrane
Y	0006508	biological_process	proteolysis
Y	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
Y	0051117	molecular_function	ATPase binding
Z	0004176	molecular_function	ATP-dependent peptidase activity
Z	0004252	molecular_function	serine-type endopeptidase activity
Z	0005737	cellular_component	cytoplasm
Z	0005886	cellular_component	plasma membrane
Z	0006508	biological_process	proteolysis
Z	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
Z	0051117	molecular_function	ATPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue ZIL A 301

Chain	Residue
A	GLY81
A	GLY82
A	PHE83
A	THR84
A	HIS135
A	PRO137
A	SER138
A	ILE157

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 302

Chain	Residue
A	ARG180
A	ARG161

site_id	AC3
Number of Residues	2
Details	binding site for residue DMS A 303

Chain	Residue
A	SER24
U	HIS22

site_id	AC4
Number of Residues	9
Details	binding site for residue ZIL B 301

Chain	Residue
B	GLY81
B	GLY82
B	PHE83
B	THR84
B	PRO137
B	SER138
B	ILE157
B	MET160
B	HOH401

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 B 302

Chain	Residue
A	ARG97
B	ARG207

site_id	AC6
Number of Residues	2
Details	binding site for residue DMS B 303

Chain	Residue
B	SER24
T	HIS22

site_id	AC7
Number of Residues	1
Details	binding site for residue DMS B 304

Chain	Residue
B	ARG180

site_id	AC8
Number of Residues	9
Details	binding site for residue ZIL C 301

Chain	Residue
C	GLY81
C	GLY82
C	PHE83
C	THR84
C	PRO137
C	SER138
C	ILE157
C	MET160
C	HOH401

site_id	AC9
Number of Residues	1
Details	binding site for residue SO4 C 302

Chain	Residue
C	ARG180

site_id	AD1
Number of Residues	2
Details	binding site for residue SO4 C 303

Chain	Residue
C	ARG70
C	ASP71

site_id	AD2
Number of Residues	2
Details	binding site for residue SO4 C 304

Chain	Residue
B	ARG97
C	ARG207

site_id	AD3
Number of Residues	1
Details	binding site for residue SO4 C 305

Chain	Residue
C	ARG207

site_id	AD4
Number of Residues	2
Details	binding site for residue DMS C 306

Chain	Residue
C	SER24
S	HIS22

site_id	AD5
Number of Residues	9
Details	binding site for residue ZIL D 301

Chain	Residue
D	GLY81
D	GLY82
D	PHE83
D	THR84
D	PRO137
D	SER138
D	ILE157
D	MET164
D	HOH401

site_id	AD6
Number of Residues	1
Details	binding site for residue SO4 D 302

Chain	Residue
D	ARG180

site_id	AD7
Number of Residues	1
Details	binding site for residue DMS D 303

Chain	Residue
D	SER24

site_id	AD8
Number of Residues	9
Details	binding site for residue ZIL E 301

Chain	Residue
E	GLY81
E	GLY82
E	PHE83
E	THR84
E	PRO137
E	SER138
E	ILE157
E	MET164
E	HOH402

site_id	AD9
Number of Residues	2
Details	binding site for residue SO4 E 302

Chain	Residue
E	ARG70
E	ASP71

site_id	AE1
Number of Residues	1
Details	binding site for residue SO4 E 303

Chain	Residue
E	ARG180

site_id	AE2
Number of Residues	1
Details	binding site for residue SO4 E 304

Chain	Residue
E	LYS187

site_id	AE3
Number of Residues	2
Details	binding site for residue SO4 E 305

Chain	Residue
E	ARG97
F	ARG207

site_id	AE4
Number of Residues	2
Details	binding site for residue DMS E 306

Chain	Residue
E	SER24
Q	HIS22

site_id	AE5
Number of Residues	8
Details	binding site for residue ZIL F 301

Chain	Residue
F	GLY81
F	GLY82
F	PHE83
F	THR84
F	PRO137
F	SER138
F	ILE157
F	HOH401

site_id	AE6
Number of Residues	2
Details	binding site for residue SO4 F 302

Chain	Residue
F	ARG161
F	ARG180

site_id	AE7
Number of Residues	2
Details	binding site for residue DMS F 303

Chain	Residue
F	SER24
P	HIS22

site_id	AE8
Number of Residues	9
Details	binding site for residue ZIL G 301

Chain	Residue
A	ARG131
G	GLY81
G	GLY82
G	PHE83
G	THR84
G	PRO137
G	SER138
G	ILE157
G	MET160

site_id	AE9
Number of Residues	1
Details	binding site for residue SO4 G 302

Chain	Residue
G	ARG70

site_id	AF1
Number of Residues	1
Details	binding site for residue SO4 G 303

Chain	Residue
G	ARG180

site_id	AF2
Number of Residues	2
Details	binding site for residue DMS G 304

Chain	Residue
G	SER24
O	HIS22

site_id	AF3
Number of Residues	8
Details	binding site for residue ZIL H 301

Chain	Residue
H	MSE99
H	HIS123
H	PRO125
H	LEU126
N	ARG119
H	GLY69
H	SER70
H	ILE71

site_id	AF4
Number of Residues	9
Details	binding site for residue ZIL I 301

Chain	Residue
H	ARG119
I	GLY69
I	SER70
I	ILE71
I	MSE99
I	HIS123
I	PRO125
I	LEU126
I	PHE143

site_id	AF5
Number of Residues	2
Details	binding site for residue SO4 I 302

Chain	Residue
I	ARG164
I	ARG173

site_id	AF6
Number of Residues	8
Details	binding site for residue ZIL J 301

Chain	Residue
I	ARG119
J	GLY69
J	SER70
J	ILE71
J	MSE99
J	HIS123
J	PRO125
J	LEU126

site_id	AF7
Number of Residues	2
Details	binding site for residue SO4 J 302

Chain	Residue
J	ARG164
J	ARG173

site_id	AF8
Number of Residues	7
Details	binding site for residue ZIL K 301

Chain	Residue
J	ARG119
K	GLY69
K	SER70
K	ILE71
K	HIS123
K	PRO125
K	LEU126

site_id	AF9
Number of Residues	8
Details	binding site for residue ZIL L 301

Chain	Residue
L	GLY69
L	SER70
L	ILE71
L	SER98
L	MSE99
L	HIS123
L	PRO125
L	LEU126

site_id	AG1
Number of Residues	7
Details	binding site for residue ZIL M 301

Chain	Residue
M	GLY69
M	SER70
M	ILE71
M	SER98
M	HIS123
M	PRO125
M	LEU126

site_id	AG2
Number of Residues	3
Details	binding site for residue SO4 M 302

Chain	Residue
J	ARG164
J	GLU182
M	LYS58

site_id	AG3
Number of Residues	7
Details	binding site for residue ZIL N 301

Chain	Residue
N	GLY69
N	SER70
N	ILE71
N	HIS123
N	PRO125
N	LEU126
N	GLY127

site_id	AG4
Number of Residues	9
Details	binding site for residue ZIL O 301

Chain	Residue
O	GLY81
O	GLY82
O	PHE83
O	THR84
O	PRO137
O	SER138
O	ILE157
O	MET160
P	ARG131

site_id	AG5
Number of Residues	2
Details	binding site for residue SO4 O 302

Chain	Residue
O	ARG161
O	ARG180

site_id	AG6
Number of Residues	2
Details	binding site for residue SO4 O 303

Chain	Residue
O	ARG207
U	ARG97

site_id	AG7
Number of Residues	2
Details	binding site for residue DMS O 304

Chain	Residue
G	HIS22
O	SER24

site_id	AG8
Number of Residues	8
Details	binding site for residue ZIL P 301

Chain	Residue
P	GLY81
P	GLY82
P	PHE83
P	THR84
P	HIS135
P	PRO137
P	SER138
P	ILE157

site_id	AG9
Number of Residues	2
Details	binding site for residue SO4 P 302

Chain	Residue
P	ARG97
Q	ARG207

site_id	AH1
Number of Residues	2
Details	binding site for residue SO4 P 303

Chain	Residue
P	ARG161
P	ARG180

site_id	AH2
Number of Residues	2
Details	binding site for residue SO4 P 304

Chain	Residue
P	ARG70
P	ASP71

site_id	AH3
Number of Residues	2
Details	binding site for residue DMS P 305

Chain	Residue
F	HIS22
P	SER24

site_id	AH4
Number of Residues	10
Details	binding site for residue ZIL Q 301

Chain	Residue
Q	GLY81
Q	GLY82
Q	PHE83
Q	THR84
Q	PRO137
Q	SER138
Q	ILE157
Q	MET160
Q	MET164
Q	HOH401

site_id	AH5
Number of Residues	1
Details	binding site for residue SO4 Q 302

Chain	Residue
Q	ARG180

site_id	AH6
Number of Residues	2
Details	binding site for residue SO4 Q 303

Chain	Residue
Q	ARG97
R	ARG207

site_id	AH7
Number of Residues	2
Details	binding site for residue DMS Q 304

Chain	Residue
E	HIS22
Q	SER24

site_id	AH8
Number of Residues	10
Details	binding site for residue ZIL R 301

Chain	Residue
R	GLY81
R	GLY82
R	PHE83
R	THR84
R	HIS135
R	PRO137
R	SER138
R	ILE157
R	MET164
R	HOH401

site_id	AH9
Number of Residues	2
Details	binding site for residue SO4 R 302

Chain	Residue
R	ARG70
R	ASP71

site_id	AI1
Number of Residues	1
Details	binding site for residue SO4 R 303

Chain	Residue
R	LYS187

site_id	AI2
Number of Residues	1
Details	binding site for residue SO4 R 304

Chain	Residue
R	ARG180

site_id	AI3
Number of Residues	1
Details	binding site for residue DMS R 305

Chain	Residue
R	SER24

site_id	AI4
Number of Residues	10
Details	binding site for residue ZIL S 301

Chain	Residue
S	GLY81
S	GLY82
S	PHE83
S	THR84
S	HIS135
S	PRO137
S	SER138
S	ILE157
S	MET160
S	MET164

site_id	AI5
Number of Residues	2
Details	binding site for residue SO4 S 302

Chain	Residue
R	ARG97
S	ARG207

site_id	AI6
Number of Residues	1
Details	binding site for residue SO4 S 303

Chain	Residue
S	ARG207

site_id	AI7
Number of Residues	2
Details	binding site for residue SO4 S 304

Chain	Residue
S	ARG70
S	ASP71

site_id	AI8
Number of Residues	1
Details	binding site for residue SO4 S 305

Chain	Residue
S	ARG180

site_id	AI9
Number of Residues	2
Details	binding site for residue DMS S 306

Chain	Residue
C	HIS22
S	SER24

site_id	AJ1
Number of Residues	9
Details	binding site for residue ZIL T 301

Chain	Residue
T	GLY81
T	GLY82
T	PHE83
T	THR84
T	PRO137
T	SER138
T	ILE157
T	MET160
T	HOH401

site_id	AJ2
Number of Residues	2
Details	binding site for residue SO4 T 302

Chain	Residue
T	ARG161
T	ARG180

site_id	AJ3
Number of Residues	2
Details	binding site for residue DMS T 303

Chain	Residue
B	HIS22
T	SER24

site_id	AJ4
Number of Residues	9
Details	binding site for residue ZIL U 301

Chain	Residue
U	GLY81
U	GLY82
U	PHE83
U	THR84
U	PRO137
U	SER138
U	ILE157
U	MET164
U	HOH401

site_id	AJ5
Number of Residues	1
Details	binding site for residue SO4 U 302

Chain	Residue
U	ARG180

site_id	AJ6
Number of Residues	1
Details	binding site for residue DMS U 303

Chain	Residue
U	SER24

site_id	AJ7
Number of Residues	6
Details	binding site for residue ZIL V 301

Chain	Residue
V	GLY69
V	SER70
V	ILE71
V	HIS123
V	LEU126
b	ARG119

site_id	AJ8
Number of Residues	8
Details	binding site for residue ZIL W 301

Chain	Residue
V	ARG119
W	GLY69
W	SER70
W	ILE71
W	SER98
W	HIS123
W	PRO125
W	LEU126

site_id	AJ9
Number of Residues	2
Details	binding site for residue SO4 W 302

Chain	Residue
W	ARG164
W	ARG173

site_id	AK1
Number of Residues	9
Details	binding site for residue ZIL X 301

Chain	Residue
X	GLY69
X	SER70
X	ILE71
X	SER98
X	MSE99
X	HIS123
X	LEU126
X	PHE143
X	ILE146

site_id	AK2
Number of Residues	7
Details	binding site for residue ZIL Y 301

Chain	Residue
X	ARG119
Y	GLY69
Y	SER70
Y	ILE71
Y	HIS123
Y	PRO125
Y	LEU126

site_id	AK3
Number of Residues	7
Details	binding site for residue ZIL Z 301

Chain	Residue
Y	ARG119
Z	GLY69
Z	SER70
Z	ILE71
Z	HIS123
Z	LEU126
Z	GLY127

site_id	AK4
Number of Residues	8
Details	binding site for residue ZIL a 301

Chain	Residue
Z	ARG119
a	GLY69
a	SER70
a	ILE71
a	SER98
a	HIS123
a	PRO125
a	LEU126

site_id	AK5
Number of Residues	7
Details	binding site for residue ZIL b 301

Chain	Residue
a	ARG119
b	GLY69
b	SER70
b	ILE71
b	SER98
b	HIS123
b	LEU126

site_id	AK6
Number of Residues	8
Details	binding site for Ligand ARG A 97 bound to THR c 3

Chain	Residue
A	GLU64
A	TYR95
A	VAL96
A	ALA98
B	ARG207
B	SO4302
c	THR3
c	PRO4

site_id	AK7
Number of Residues	9
Details	binding site for Ligand ARG R 97 bound to THR m 3

Chain	Residue
R	GLU64
R	TYR95
R	VAL96
R	ALA98
S	ARG207
S	LEU209
S	SO4302
m	THR3
m	PRO4

site_id	AK8
Number of Residues	7
Details	binding site for Ligand ARG S 97 bound to THR n 3

Chain	Residue
S	GLU64
S	TYR95
S	VAL96
S	ALA98
T	LEU209
n	THR3
n	PRO4

site_id	AK9
Number of Residues	9
Details	binding site for Ligand ARG U 97 bound to THR p 3

Chain	Residue
O	ARG207
O	LEU209
O	SO4303
U	GLU64
U	TYR95
U	VAL96
U	ALA98
p	THR3
p	PRO4

site_id	AL1
Number of Residues	8
Details	binding site for Di-peptide SO4 p 101 and PRO p 4

Chain	Residue
O	ARG207
U	TYR95
U	ARG97
p	WFP2
p	THR3
p	3A05
p	ALA6
p	PRO7

site_id	AL2
Number of Residues	13
Details	binding site for ADEP-2B5Me chain c

Chain	Residue
A	LEU61
A	THR92
A	TYR95
A	ARG97
B	LYS35
B	LEU36
B	GLU39
B	THR73
B	TYR75
B	GLN101
B	VAL103
B	LEU105
B	MET125

site_id	AL3
Number of Residues	13
Details	binding site for ADEP-2B5Me chain i

Chain	Residue
A	LYS35
A	LEU36
A	GLU39
A	THR73
A	TYR75
A	GLN101
A	LEU105
A	MET125
A	LEU127
G	LEU61
G	THR92
G	TYR95
G	ARG97

site_id	AL4
Number of Residues	12
Details	binding site for ADEP-2B5Me chain d

Chain	Residue
B	LEU61
B	TYR95
B	ARG97
C	LYS35
C	LEU36
C	GLU39
C	THR73
C	TYR75
C	GLN101
C	LEU105
C	MET125
C	LEU127

site_id	AL5
Number of Residues	14
Details	binding site for ADEP-2B5Me chain e

Chain	Residue
C	LEU61
C	THR92
C	TYR95
D	LYS35
D	LEU36
D	GLU39
D	ILE41
D	THR73
D	TYR75
D	GLN101
D	LEU105
D	MET125
W	PRO85
W	ASP87

site_id	AL6
Number of Residues	12
Details	binding site for ADEP-2B5Me chain f

Chain	Residue
D	LEU61
D	THR92
D	TYR95
D	ARG97
E	LYS35
E	LEU36
E	GLU39
E	TYR75
E	GLN101
E	VAL103
E	LEU105
E	MET125

site_id	AL7
Number of Residues	14
Details	binding site for ADEP-2B5Me chain g

Chain	Residue
E	LEU61
E	THR92
E	TYR95
E	ARG97
F	LYS35
F	LEU36
F	GLU39
F	ILE41
F	TYR75
F	GLN101
F	VAL103
F	LEU105
F	MET125
F	ARG207

site_id	AL8
Number of Residues	12
Details	binding site for ADEP-2B5Me chain h

Chain	Residue
F	LEU61
F	THR92
F	TYR95
F	ARG97
G	LYS35
G	LEU36
G	GLU39
G	THR73
G	TYR75
G	GLN101
G	LEU105
G	MET125

site_id	AL9
Number of Residues	14
Details	binding site for ADEP-2B5Me chain j

Chain	Residue
O	LEU61
O	THR92
O	TYR95
O	ARG97
P	LYS35
P	LEU36
P	THR73
P	TYR75
P	GLN101
P	VAL103
P	LEU105
P	MET125
P	LEU127
P	LEU204

site_id	AM1
Number of Residues	13
Details	binding site for ADEP-2B5Me chain k

Chain	Residue
P	LEU61
P	THR92
P	TYR95
P	ARG97
Q	LYS35
Q	LEU36
Q	GLU39
Q	THR73
Q	TYR75
Q	GLN101
Q	LEU105
Q	MET125
Q	LEU127

site_id	AM2
Number of Residues	15
Details	binding site for ADEP-2B5Me chain l

Chain	Residue
Q	LEU61
Q	THR92
Q	TYR95
Q	ARG97
R	LYS35
R	LEU36
R	GLU39
R	ILE41
R	THR73
R	TYR75
R	GLN101
R	VAL103
R	LEU105
R	MET125
R	ARG207

site_id	AM3
Number of Residues	12
Details	binding site for ADEP-2B5Me chain m

Chain	Residue
R	LEU61
R	THR92
R	TYR95
R	ARG97
S	LYS35
S	LEU36
S	GLU39
S	THR73
S	TYR75
S	GLN101
S	LEU105
S	ARG207

site_id	AM4
Number of Residues	12
Details	binding site for ADEP-2B5Me chain n

Chain	Residue
S	LEU61
S	THR92
S	TYR95
S	ARG97
T	LYS35
T	LEU36
T	GLU39
T	THR73
T	TYR75
T	GLN101
T	LEU105
T	LEU127

site_id	AM5
Number of Residues	12
Details	binding site for ADEP-2B5Me chain o

Chain	Residue
T	LEU61
T	THR92
T	TYR95
T	ARG97
U	LYS35
U	LEU36
U	GLU39
U	THR73
U	TYR75
U	GLN101
U	LEU105
U	MET125

site_id	AM6
Number of Residues	14
Details	binding site for ADEP-2B5Me chain p

Chain	Residue
O	LYS35
O	LEU36
O	GLU39
O	THR73
O	TYR75
O	GLN101
O	LEU105
O	MET125
O	ARG207
U	LEU61
U	THR92
U	TYR95
U	ARG97
p	SO4101

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TvcLGqAASAAA

Chain	Residue	Details
A	THR102-ALA113

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RyalPharILMHQP

Chain	Residue	Details
a	ARG112-PRO125
A	ARG124-PRO137

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	28
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)