4U01
HCV NS3/4A serine protease in complex with 6570
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0019087 | biological_process | transformation of host cell by virus |
| B | 0006508 | biological_process | proteolysis |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0019087 | biological_process | transformation of host cell by virus |
| C | 0006508 | biological_process | proteolysis |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0019087 | biological_process | transformation of host cell by virus |
| D | 0006508 | biological_process | proteolysis |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0019087 | biological_process | transformation of host cell by virus |
| E | 0006508 | biological_process | proteolysis |
| E | 0008236 | molecular_function | serine-type peptidase activity |
| E | 0019087 | biological_process | transformation of host cell by virus |
| F | 0006508 | biological_process | proteolysis |
| F | 0008236 | molecular_function | serine-type peptidase activity |
| F | 0019087 | biological_process | transformation of host cell by virus |
| G | 0006508 | biological_process | proteolysis |
| G | 0008236 | molecular_function | serine-type peptidase activity |
| G | 0019087 | biological_process | transformation of host cell by virus |
| H | 0006508 | biological_process | proteolysis |
| H | 0008236 | molecular_function | serine-type peptidase activity |
| H | 0019087 | biological_process | transformation of host cell by virus |
| J | 0006508 | biological_process | proteolysis |
| J | 0008236 | molecular_function | serine-type peptidase activity |
| J | 0019087 | biological_process | transformation of host cell by virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue 39W A 301 |
| Chain | Residue |
| A | PHE43 |
| A | SER139 |
| A | PHE154 |
| A | ARG155 |
| A | ALA156 |
| A | ALA157 |
| A | CYS159 |
| D | ASP79 |
| D | 39W301 |
| A | HIS57 |
| A | GLY58 |
| A | ASP79 |
| A | ASP81 |
| A | VAL132 |
| A | LYS136 |
| A | GLY137 |
| A | SER138 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 302 |
| Chain | Residue |
| A | CYS97 |
| A | CYS99 |
| A | CYS145 |
| A | SER147 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue 39W B 301 |
| Chain | Residue |
| B | SER42 |
| B | PHE43 |
| B | HIS57 |
| B | ASP79 |
| B | VAL132 |
| B | LEU135 |
| B | LYS136 |
| B | GLY137 |
| B | SER138 |
| B | SER139 |
| B | PHE154 |
| B | ARG155 |
| B | ALA156 |
| B | ALA157 |
| F | VAL78 |
| F | ASP79 |
| F | 39W301 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 302 |
| Chain | Residue |
| B | CYS97 |
| B | THR98 |
| B | CYS99 |
| B | CYS145 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | binding site for residue 39W C 301 |
| Chain | Residue |
| C | PHE43 |
| C | TYR56 |
| C | HIS57 |
| C | GLY58 |
| C | ASP79 |
| C | ASP81 |
| C | VAL132 |
| C | LYS136 |
| C | GLY137 |
| C | SER138 |
| C | SER139 |
| C | PHE154 |
| C | ARG155 |
| C | ALA156 |
| C | ALA157 |
| E | VAL78 |
| E | ASP79 |
| E | 39W301 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue ZN C 302 |
| Chain | Residue |
| C | CYS97 |
| C | CYS99 |
| C | CYS145 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | binding site for residue 39W D 301 |
| Chain | Residue |
| A | VAL78 |
| A | ASP79 |
| A | 39W301 |
| D | GLN41 |
| D | PHE43 |
| D | HIS57 |
| D | GLY58 |
| D | ASP79 |
| D | GLN80 |
| D | ASP81 |
| D | VAL132 |
| D | LYS136 |
| D | GLY137 |
| D | SER138 |
| D | SER139 |
| D | PHE154 |
| D | ARG155 |
| D | ALA156 |
| D | ALA157 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 302 |
| Chain | Residue |
| D | CYS97 |
| D | CYS99 |
| D | CYS145 |
| D | SER147 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue CL D 303 |
| Chain | Residue |
| D | SER37 |
| site_id | AD1 |
| Number of Residues | 17 |
| Details | binding site for residue 39W E 301 |
| Chain | Residue |
| E | SER138 |
| E | SER139 |
| E | PHE154 |
| E | ARG155 |
| E | ALA157 |
| C | 39W301 |
| E | PHE43 |
| E | TYR56 |
| E | HIS57 |
| E | GLY58 |
| E | ASP79 |
| E | GLN80 |
| E | ASP81 |
| E | VAL132 |
| E | LEU135 |
| E | LYS136 |
| E | GLY137 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 302 |
| Chain | Residue |
| E | CYS97 |
| E | CYS99 |
| E | CYS145 |
| E | SER147 |
| site_id | AD3 |
| Number of Residues | 19 |
| Details | binding site for residue 39W F 301 |
| Chain | Residue |
| B | 39W301 |
| F | GLN41 |
| F | PHE43 |
| F | TYR56 |
| F | HIS57 |
| F | GLY58 |
| F | ASP79 |
| F | GLN80 |
| F | ASP81 |
| F | VAL132 |
| F | LEU135 |
| F | LYS136 |
| F | GLY137 |
| F | SER138 |
| F | SER139 |
| F | PHE154 |
| F | ARG155 |
| F | ALA156 |
| F | ALA157 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue ZN F 302 |
| Chain | Residue |
| F | CYS97 |
| F | CYS99 |
| F | CYS145 |
| site_id | AD5 |
| Number of Residues | 16 |
| Details | binding site for residue 39W G 301 |
| Chain | Residue |
| G | PHE43 |
| G | HIS57 |
| G | ASP79 |
| G | ASP81 |
| G | VAL132 |
| G | LYS136 |
| G | GLY137 |
| G | SER138 |
| G | SER139 |
| G | PHE154 |
| G | ARG155 |
| G | ALA156 |
| G | ALA157 |
| H | VAL78 |
| H | ASP79 |
| H | 39W301 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN G 302 |
| Chain | Residue |
| G | CYS97 |
| G | THR98 |
| G | CYS99 |
| G | CYS145 |
| site_id | AD7 |
| Number of Residues | 19 |
| Details | binding site for residue 39W H 301 |
| Chain | Residue |
| G | VAL78 |
| G | ASP79 |
| G | 39W301 |
| H | GLN41 |
| H | PHE43 |
| H | TYR56 |
| H | HIS57 |
| H | ASP79 |
| H | ASP81 |
| H | VAL132 |
| H | LEU135 |
| H | LYS136 |
| H | GLY137 |
| H | SER138 |
| H | SER139 |
| H | PHE154 |
| H | ARG155 |
| H | ALA156 |
| H | ALA157 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue ZN H 302 |
| Chain | Residue |
| H | CYS97 |
| H | CYS99 |
| H | CYS145 |
| site_id | AD9 |
| Number of Residues | 21 |
| Details | binding site for residue 39W J 301 |
| Chain | Residue |
| J | GLN41 |
| J | PHE43 |
| J | TYR56 |
| J | HIS57 |
| J | GLY58 |
| J | VAL78 |
| J | ASP79 |
| J | ASP79 |
| J | GLN80 |
| J | ASP81 |
| J | VAL132 |
| J | LEU135 |
| J | LYS136 |
| J | GLY137 |
| J | SER138 |
| J | SER139 |
| J | PHE154 |
| J | ARG155 |
| J | ALA156 |
| J | ALA157 |
| J | CYS159 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN J 302 |
| Chain | Residue |
| J | CYS97 |
| J | CYS99 |
| J | GLY100 |
| J | SER101 |
| J | CYS145 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 27 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 |
| Chain | Residue | Details |
| A | HIS57 | |
| D | HIS57 | |
| D | ASP81 | |
| D | SER139 | |
| E | HIS57 | |
| E | ASP81 | |
| E | SER139 | |
| F | HIS57 | |
| F | ASP81 | |
| F | SER139 | |
| G | HIS57 | |
| A | ASP81 | |
| G | ASP81 | |
| G | SER139 | |
| H | HIS57 | |
| H | ASP81 | |
| H | SER139 | |
| J | HIS57 | |
| J | ASP81 | |
| J | SER139 | |
| A | SER139 | |
| B | HIS57 | |
| B | ASP81 | |
| B | SER139 | |
| C | HIS57 | |
| C | ASP81 | |
| C | SER139 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 27 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000269|PubMed:26410074 |
| Chain | Residue | Details |
| A | CYS97 | |
| D | CYS97 | |
| D | CYS99 | |
| D | CYS145 | |
| E | CYS97 | |
| E | CYS99 | |
| E | CYS145 | |
| F | CYS97 | |
| F | CYS99 | |
| F | CYS145 | |
| G | CYS97 | |
| A | CYS99 | |
| G | CYS99 | |
| G | CYS145 | |
| H | CYS97 | |
| H | CYS99 | |
| H | CYS145 | |
| J | CYS97 | |
| J | CYS99 | |
| J | CYS145 | |
| A | CYS145 | |
| B | CYS97 | |
| B | CYS99 | |
| B | CYS145 | |
| C | CYS97 | |
| C | CYS99 | |
| C | CYS145 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166 |
| Chain | Residue | Details |
| A | HIS149 | |
| B | HIS149 | |
| C | HIS149 | |
| D | HIS149 | |
| E | HIS149 | |
| F | HIS149 | |
| G | HIS149 | |
| H | HIS149 | |
| J | HIS149 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | SITE: Cleavage; by protease NS2 => ECO:0000255|PROSITE-ProRule:PRU01030 |
| Chain | Residue | Details |
| A | MET0 | |
| B | MET0 | |
| C | MET0 | |
| D | MET0 | |
| E | MET0 | |
| F | MET0 | |
| G | MET0 | |
| H | MET0 | |
| J | MET0 |
