4TZ2

Fragment-Based Screening of the Bromodomain of ATAD2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006325	biological_process	chromatin organization
A	0006355	biological_process	regulation of transcription, DNA-templated
A	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 1201

Chain	Residue
A	ARG987
A	ARG990
A	ARG994
A	ARG1067
A	ARG1072
A	HOH1360

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site_id	AC2
Number of Residues	10
Details	binding site for residue TRS A 1202

Chain	Residue
A	LEU1093
A	ASP1094
A	PHE1097
A	HOH1326
A	HOH1327
A	HOH1336
A	HOH1357
A	GLU988
A	PRO1069
A	GLU1092

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site_id	AC3
Number of Residues	3
Details	binding site for residue CL A 1203

Chain	Residue
A	ARG1077
A	HOH1358
A	HOH1367

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site_id	AC4
Number of Residues	1
Details	binding site for residue CL A 1204

Chain	Residue
A	ARG1067

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site_id	AC5
Number of Residues	9
Details	binding site for residue 39R A 1205

Chain	Residue
A	VAL1008
A	TYR1021
A	MET1029
A	ILE1056
A	ASN1059
A	ASN1064
A	ILE1074
A	HOH1395
A	HOH1471

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