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4TYP

Crystal structure of an adenylate kinase mutant--AKm1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004017molecular_functionadenylate kinase activity
A0004550molecular_functionnucleoside diphosphate kinase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006139biological_processnucleobase-containing compound metabolic process
A0008270molecular_functionzinc ion binding
A0009123biological_processnucleoside monophosphate metabolic process
A0009132biological_processnucleoside diphosphate metabolic process
A0009165biological_processnucleotide biosynthetic process
A0016301molecular_functionkinase activity
A0016776molecular_functionphosphotransferase activity, phosphate group as acceptor
A0019205molecular_functionnucleobase-containing compound kinase activity
A0044209biological_processAMP salvage
A0046872molecular_functionmetal ion binding
A0046940biological_processnucleoside monophosphate phosphorylation
A0050145molecular_functionnucleoside monophosphate kinase activity
B0004017molecular_functionadenylate kinase activity
B0004550molecular_functionnucleoside diphosphate kinase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006139biological_processnucleobase-containing compound metabolic process
B0008270molecular_functionzinc ion binding
B0009123biological_processnucleoside monophosphate metabolic process
B0009132biological_processnucleoside diphosphate metabolic process
B0009165biological_processnucleotide biosynthetic process
B0016301molecular_functionkinase activity
B0016776molecular_functionphosphotransferase activity, phosphate group as acceptor
B0019205molecular_functionnucleobase-containing compound kinase activity
B0044209biological_processAMP salvage
B0046872molecular_functionmetal ion binding
B0046940biological_processnucleoside monophosphate phosphorylation
B0050145molecular_functionnucleoside monophosphate kinase activity
C0004017molecular_functionadenylate kinase activity
C0004550molecular_functionnucleoside diphosphate kinase activity
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006139biological_processnucleobase-containing compound metabolic process
C0008270molecular_functionzinc ion binding
C0009123biological_processnucleoside monophosphate metabolic process
C0009132biological_processnucleoside diphosphate metabolic process
C0009165biological_processnucleotide biosynthetic process
C0016301molecular_functionkinase activity
C0016776molecular_functionphosphotransferase activity, phosphate group as acceptor
C0019205molecular_functionnucleobase-containing compound kinase activity
C0044209biological_processAMP salvage
C0046872molecular_functionmetal ion binding
C0046940biological_processnucleoside monophosphate phosphorylation
C0050145molecular_functionnucleoside monophosphate kinase activity
D0004017molecular_functionadenylate kinase activity
D0004550molecular_functionnucleoside diphosphate kinase activity
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006139biological_processnucleobase-containing compound metabolic process
D0008270molecular_functionzinc ion binding
D0009123biological_processnucleoside monophosphate metabolic process
D0009132biological_processnucleoside diphosphate metabolic process
D0009165biological_processnucleotide biosynthetic process
D0016301molecular_functionkinase activity
D0016776molecular_functionphosphotransferase activity, phosphate group as acceptor
D0019205molecular_functionnucleobase-containing compound kinase activity
D0044209biological_processAMP salvage
D0046872molecular_functionmetal ion binding
D0046940biological_processnucleoside monophosphate phosphorylation
D0050145molecular_functionnucleoside monophosphate kinase activity
Functional Information from PDB Data
site_idAC1
Number of Residues29
Detailsbinding site for residue AP5 C 301
ChainResidue
CPRO9
CGLU57
CLEU58
CVAL59
CTHR64
CGLY85
CARG88
CGLN92
CARG123
CLEU124
CARG127
CGLY10
CTYR137
CHIS138
CARG160
CARG171
CGLY197
CGLN199
CASP200
CMET201
CVAL204
CHOH405
CGLY12
CLYS13
CGLY14
CTHR15
CTHR31
CARG36
CILE53

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN B 301
ChainResidue
BCYS130
BCYS133
BCYS150
BASP153

site_idAC3
Number of Residues25
Detailsbinding site for residue AP5 B 302
ChainResidue
BPRO9
BGLY10
BALA11
BGLY12
BLYS13
BGLY14
BTHR15
BTHR31
BGLY32
BARG36
BGLU57
BLEU58
BVAL59
BTHR64
BGLY85
BARG88
BGLN92
BARG127
BTHR136
BTYR137
BHIS138
BARG160
BARG171
BGLN199
BMET201

site_idAC4
Number of Residues4
Detailsbinding site for residue ZN A 301
ChainResidue
ACYS130
ACYS133
ACYS150
AASP153

site_idAC5
Number of Residues26
Detailsbinding site for residue AP5 A 302
ChainResidue
APRO9
AGLY10
AALA11
AGLY12
ALYS13
AGLY14
ATHR15
ATHR31
AGLY32
APHE35
AARG36
AGLU57
AVAL59
ATHR64
AGLY85
APHE86
AARG88
AGLN92
AARG123
ALEU124
AARG127
AHIS138
AARG160
AARG171
AGLN199
AMET201

site_idAC6
Number of Residues29
Detailsbinding site for residue AP5 D 301
ChainResidue
DGLU57
DVAL59
DTHR64
DGLY85
DPHE86
DARG88
DGLN92
DARG123
DLEU124
DARG127
DTHR136
DTYR137
DHIS138
DPHE141
DARG160
DARG171
DGLY197
DGLN199
DPRO9
DGLY10
DALA11
DGLY12
DLYS13
DGLY14
DTHR15
DTHR31
DGLY32
DPHE35
DARG36

Functional Information from PROSITE/UniProt
site_idPS00113
Number of Residues12
DetailsADENYLATE_KINASE Adenylate kinase signature. FLLDGFPRtvaQ
ChainResidueDetails
CPHE81-GLN92

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues60
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00235, ECO:0000269|PubMed:15100224, ECO:0000269|PubMed:16713575
ChainResidueDetails
CGLY10
CTHR136
CCYS150
CASP153
CARG160
CARG171
CGLN199
BGLY10
BTHR31
BARG36
BGLU57
CTHR31
BGLY85
BGLN92
BARG127
BCYS130
BCYS133
BTHR136
BCYS150
BASP153
BARG160
BARG171
CARG36
BGLN199
AGLY10
ATHR31
AARG36
AGLU57
AGLY85
AGLN92
AARG127
ACYS130
ACYS133
CGLU57
ATHR136
ACYS150
AASP153
AARG160
AARG171
AGLN199
DGLY10
DTHR31
DARG36
DGLU57
CGLY85
DGLY85
DGLN92
DARG127
DCYS130
DCYS133
DTHR136
DCYS150
DASP153
DARG160
DARG171
CGLN92
DGLN199
CARG127
CCYS130
CCYS133

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PDB entries from 2024-11-06

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