4TYA

An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001172	biological_process	RNA-templated transcription
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0033644	cellular_component	host cell membrane
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0039654	biological_process	fusion of virus membrane with host endosome membrane
A	0039694	biological_process	viral RNA genome replication
B	0000166	molecular_function	nucleotide binding
B	0001172	biological_process	RNA-templated transcription
B	0003723	molecular_function	RNA binding
B	0003968	molecular_function	RNA-dependent RNA polymerase activity
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0033644	cellular_component	host cell membrane
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0039654	biological_process	fusion of virus membrane with host endosome membrane
B	0039694	biological_process	viral RNA genome replication
C	0000166	molecular_function	nucleotide binding
C	0001172	biological_process	RNA-templated transcription
C	0003723	molecular_function	RNA binding
C	0003968	molecular_function	RNA-dependent RNA polymerase activity
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0033644	cellular_component	host cell membrane
C	0034062	molecular_function	5'-3' RNA polymerase activity
C	0039654	biological_process	fusion of virus membrane with host endosome membrane
C	0039694	biological_process	viral RNA genome replication
D	0000166	molecular_function	nucleotide binding
D	0001172	biological_process	RNA-templated transcription
D	0003723	molecular_function	RNA binding
D	0003968	molecular_function	RNA-dependent RNA polymerase activity
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0033644	cellular_component	host cell membrane
D	0034062	molecular_function	5'-3' RNA polymerase activity
D	0039654	biological_process	fusion of virus membrane with host endosome membrane
D	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue 3AE A 601

Chain	Residue
A	PHE193
A	ARG200
A	CYS366
A	SER368
A	LEU384
A	MET414
A	TYR415

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site_id	AC2
Number of Residues	3
Details	binding site for residue 3AE B 601

Chain	Residue
B	TYR415
B	CYS366
B	LEU384

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site_id	AC3
Number of Residues	7
Details	binding site for residue 3AE C 601

Chain	Residue
C	ARG200
C	CYS366
C	SER368
C	LEU384
C	MET414
C	TYR415
C	TYR448

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site_id	AC4
Number of Residues	7
Details	binding site for residue 3AE D 601

Chain	Residue
D	ARG200
D	CYS366
D	SER368
D	LEU384
D	MET414
D	TYR415
D	TYR448

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