4TXM
Crystal structure of uridine phosphorylase from Schistosoma mansoni in complex with thymine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006218 | biological_process | uridine catabolic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044206 | biological_process | UMP salvage |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006218 | biological_process | uridine catabolic process |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009166 | biological_process | nucleotide catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0044206 | biological_process | UMP salvage |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | GLY46 |
| A | ARG50 |
| A | ARG121 |
| A | GLY123 |
| A | THR124 |
| A | HOH576 |
| A | HOH578 |
| B | ARG77 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue TDR A 302 |
| Chain | Residue |
| A | SER125 |
| A | GLY126 |
| A | PHE197 |
| A | GLN201 |
| A | ARG203 |
| A | MET231 |
| A | GLU232 |
| A | MET233 |
| A | HOH472 |
| A | HOH555 |
| A | HOH576 |
| A | THR124 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 301 |
| Chain | Residue |
| A | ARG77 |
| B | CYS45 |
| B | GLY46 |
| B | ARG50 |
| B | ARG121 |
| B | GLY123 |
| B | THR124 |
| B | HOH531 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue TDR B 302 |
| Chain | Residue |
| B | THR124 |
| B | SER125 |
| B | GLY126 |
| B | PHE197 |
| B | GLN201 |
| B | ARG203 |
| B | MET231 |
| B | GLU232 |
| B | MET233 |
| B | ILE265 |
| B | HOH527 |
| B | HOH530 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q16831","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26898674","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TXJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TXM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TXN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26898674","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TXJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TXN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
