4TTC
Crystal structure of homo sapiens IODOTYROSINE DEIODINASE bound to FMN and mono-iodotyrosine (MIT)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue FMN A 301 |
| Chain | Residue |
| A | ARG100 |
| A | ARG279 |
| A | IYR302 |
| A | HOH425 |
| A | HOH426 |
| A | HOH427 |
| B | PRO127 |
| B | SER128 |
| B | GLY129 |
| B | HIS131 |
| B | TYR212 |
| A | ARG101 |
| B | ILE215 |
| B | SER216 |
| A | SER102 |
| A | ARG104 |
| A | LEU176 |
| A | THR178 |
| A | THR237 |
| A | THR238 |
| A | THR239 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue IYR A 302 |
| Chain | Residue |
| A | GLU157 |
| A | TYR161 |
| A | LEU173 |
| A | LEU176 |
| A | THR178 |
| A | ASN179 |
| A | LYS182 |
| A | FMN301 |
| A | HOH437 |
| B | ALA130 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue FMN B 301 |
| Chain | Residue |
| A | PRO127 |
| A | SER128 |
| A | GLY129 |
| A | TYR212 |
| A | SER216 |
| B | ARG100 |
| B | ARG101 |
| B | SER102 |
| B | ARG104 |
| B | LEU176 |
| B | VAL236 |
| B | THR237 |
| B | THR238 |
| B | THR239 |
| B | LEU277 |
| B | ARG279 |
| B | IYR302 |
| B | HOH404 |
| B | HOH413 |
| B | HOH424 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue IYR B 302 |
| Chain | Residue |
| A | ALA130 |
| B | GLU157 |
| B | TYR161 |
| B | LEU173 |
| B | LEU176 |
| B | THR178 |
| B | ASN179 |
| B | LYS182 |
| B | FMN301 |
| B | HOH435 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue FMN C 301 |
| Chain | Residue |
| C | ARG100 |
| C | ARG101 |
| C | SER102 |
| C | ARG104 |
| C | LEU176 |
| C | THR178 |
| C | VAL236 |
| C | THR237 |
| C | THR238 |
| C | THR239 |
| C | ARG279 |
| C | IYR302 |
| C | HOH409 |
| C | HOH411 |
| C | HOH415 |
| C | HOH416 |
| D | PRO127 |
| D | SER128 |
| D | GLY129 |
| D | TYR212 |
| D | SER216 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue IYR C 302 |
| Chain | Residue |
| C | GLU157 |
| C | TYR161 |
| C | TRP169 |
| C | LEU173 |
| C | LEU176 |
| C | THR178 |
| C | LYS182 |
| C | FMN301 |
| D | ALA130 |
| D | TYR211 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | binding site for residue FMN D 301 |
| Chain | Residue |
| D | ARG101 |
| D | SER102 |
| D | ARG104 |
| D | LEU176 |
| D | VAL236 |
| D | THR237 |
| D | THR238 |
| D | THR239 |
| D | ARG279 |
| D | IYR302 |
| D | HOH410 |
| D | HOH416 |
| C | PRO127 |
| C | SER128 |
| C | GLY129 |
| C | HIS131 |
| C | TYR212 |
| C | SER216 |
| D | ARG100 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue IYR D 302 |
| Chain | Residue |
| C | ALA130 |
| D | GLU157 |
| D | TYR161 |
| D | LEU173 |
| D | LEU176 |
| D | ASN179 |
| D | LYS182 |
| D | THR239 |
| D | FMN301 |
| D | HOH412 |
| site_id | AC9 |
| Number of Residues | 22 |
| Details | binding site for residue FMN E 301 |
| Chain | Residue |
| E | ARG100 |
| E | ARG101 |
| E | SER102 |
| E | ARG104 |
| E | LEU176 |
| E | THR178 |
| E | VAL236 |
| E | THR237 |
| E | THR238 |
| E | THR239 |
| E | ARG279 |
| E | IYR302 |
| E | HOH406 |
| E | HOH410 |
| E | HOH420 |
| F | PRO127 |
| F | SER128 |
| F | GLY129 |
| F | HIS131 |
| F | TYR212 |
| F | SER216 |
| F | HOH405 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue IYR E 302 |
| Chain | Residue |
| E | GLU157 |
| E | TYR161 |
| E | LEU173 |
| E | LEU176 |
| E | THR178 |
| E | ASN179 |
| E | LYS182 |
| E | THR239 |
| E | FMN301 |
| F | ALA130 |
| site_id | AD2 |
| Number of Residues | 21 |
| Details | binding site for residue FMN F 301 |
| Chain | Residue |
| E | PRO127 |
| E | SER128 |
| E | GLY129 |
| E | TYR212 |
| E | ILE215 |
| E | SER216 |
| F | ARG100 |
| F | ARG101 |
| F | SER102 |
| F | ARG104 |
| F | LEU176 |
| F | THR178 |
| F | VAL236 |
| F | THR237 |
| F | THR238 |
| F | THR239 |
| F | ARG279 |
| F | IYR302 |
| F | HOH404 |
| F | HOH406 |
| F | HOH409 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue IYR F 302 |
| Chain | Residue |
| E | ALA130 |
| F | GLU157 |
| F | TYR161 |
| F | LEU173 |
| F | LEU176 |
| F | THR178 |
| F | ASN179 |
| F | LYS182 |
| F | FMN301 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25395621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TTC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9DCX8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25395621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TTC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"4TTC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
