Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR CHAIN D OF L-ALPHA-GLUTAMYL-L-ISOLEUCYL-N-[(2R,3S)-1-{[(1S)-1- CARBOXYBUTYL]AMINO}-2-HYDROXY-5-METHYLHEXAN-3-YL]-3-THIOPHEN-2-YL-L- ALANINAMIDE |
| Chain | Residue |
| A | GLY72 |
| A | ASP289 |
| A | GLY291 |
| A | THR292 |
| A | THR293 |
| A | ASN294 |
| A | GLY74 |
| A | ASP93 |
| A | GLY95 |
| A | TYR132 |
| A | THR133 |
| A | GLN134 |
| A | ILE171 |
| A | TYR259 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR CHAIN E OF L-ALPHA-GLUTAMYL-L-ISOLEUCYL-N-[(2R,3S)-1-{[(1S)-1- CARBOXYBUTYL]AMINO}-2-HYDROXY-5-METHYLHEXAN-3-YL]-3-THIOPHEN-2-YL-L- ALANINAMIDE |
| Chain | Residue |
| B | GLY72 |
| B | ASP93 |
| B | GLY95 |
| B | PRO131 |
| B | TYR132 |
| B | THR133 |
| B | GLN134 |
| B | PHE169 |
| B | TYR259 |
| B | ASP289 |
| B | GLY291 |
| B | THR292 |
| B | THR293 |
| B | ASN294 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR CHAIN F OF L-ALPHA-GLUTAMYL-L-ISOLEUCYL-N-[(2R,3S)-1-{[(1S)-1- CARBOXYBUTYL]AMINO}-2-HYDROXY-5-METHYLHEXAN-3-YL]-3-THIOPHEN-2-YL-L- ALANINAMIDE |
| Chain | Residue |
| C | GLY72 |
| C | LEU91 |
| C | ASP93 |
| C | GLY95 |
| C | SER96 |
| C | PRO131 |
| C | TYR132 |
| C | THR133 |
| C | GLN134 |
| C | TYR259 |
| C | ASP289 |
| C | GLY291 |
| C | THR292 |
| C | THR293 |
| C | ASN294 |
| C | ARG296 |
| C | ARG368 |
| C | LYS382 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE90-VAL101 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1023 |
| Details | Domain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17425515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19011241","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
