4TQE

Structure of tau peptide in complex with Tau5 antibody Fab fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0005615	cellular_component	extracellular space
L	0006955	biological_process	immune response
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 L 301

Chain	Residue
H	SER120
H	SER121
H	NA302
L	SER158
L	GLU159
L	NA305
L	HOH417

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site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 L 302

Chain	Residue
L	LYS112
L	HOH416
L	HOH441
L	SER28
L	VAL30

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site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 L 303

Chain	Residue
L	ARG113
L	ASP175
L	HOH547

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site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 L 304

Chain	Residue
L	ASN166
L	TRP168
L	NA307

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site_id	AC5
Number of Residues	3
Details	binding site for residue NA L 305

Chain	Residue
H	VAL119
L	SER158
L	SO4301

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site_id	AC6
Number of Residues	4
Details	binding site for residue NA L 306

Chain	Residue
L	SER14
L	ASP17
L	LYS112
L	HOH438

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site_id	AC7
Number of Residues	2
Details	binding site for residue NA L 307

Chain	Residue
L	ASN166
L	SO4304

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site_id	AC8
Number of Residues	8
Details	binding site for residue SO4 H 301

Chain	Residue
H	SER164
H	ASN204
H	ASP215
H	HOH420
H	HOH444
L	SER61
L	GLY62
L	HOH442

---

site_id	AC9
Number of Residues	4
Details	binding site for residue NA H 302

Chain	Residue
H	SER14
H	SER121
L	SO4301
L	HOH417

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site_id	AD1
Number of Residues	5
Details	binding site for residue PGE H 303

Chain	Residue
H	GLN39
H	VAL93
H	GLN113
H	GLY114
L	GLY46

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR197-HIS203

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Not glycated => ECO:0000269|PubMed:9326300

Chain	Residue	Details
A	LYS224

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179

Chain	Residue	Details
A	THR217

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P10637

Chain	Residue	Details
A	LYS225

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro => ECO:0000269|PubMed:9326300

Chain	Residue	Details
A	LYS225

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