English 日本語简体中文繁體中文 한국어

✖

Menu

RCSB PDB PDBe BMRB Adv. Search Search help

Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4TPY

High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0007586	biological_process	digestion
A	0008236	molecular_function	serine-type peptidase activity
A	0046872	molecular_function	metal ion binding
A	0097180	cellular_component	serine protease inhibitor complex
A	0097655	molecular_function	serpin family protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 301

Chain	Residue
A	GLU52
A	ASN54
A	VAL57
A	GLU62
A	HOH590
A	HOH595

site_id	AC2
Number of Residues	4
Details	binding site for residue NA A 302

Chain	Residue
A	HOH742
A	THR80
A	ASN82
A	HOH637

site_id	AC3
Number of Residues	2
Details	binding site for residue NA A 303

Chain	Residue
A	GLN115
A	PRO141

site_id	AC4
Number of Residues	2
Details	binding site for residue NA A 304

Chain	Residue
A	ASP133
A	HOH689

site_id	AC5
Number of Residues	4
Details	binding site for residue NA A 305

Chain	Residue
A	TYR76
A	SER78
A	HOH461
A	HOH518

site_id	AC6
Number of Residues	4
Details	binding site for residue NA A 306

Chain	Residue
A	PHE64
A	EDO338
A	HOH743
A	HOH775

site_id	AC7
Number of Residues	2
Details	binding site for residue NA A 307

Chain	Residue
A	THR157
A	SER158

site_id	AC8
Number of Residues	3
Details	binding site for residue BR A 308

Chain	Residue
A	ASN77
A	ASN79
A	HOH560

site_id	AC9
Number of Residues	3
Details	binding site for residue BR A 309

Chain	Residue
A	GLN47
A	PRO74
A	SER75

site_id	AD1
Number of Residues	3
Details	binding site for residue BR A 310

Chain	Residue
A	ALA93
A	CYS109
A	BR311

site_id	AD2
Number of Residues	4
Details	binding site for residue BR A 311

Chain	Residue
A	SER92
A	ALA93
A	CYS109
A	BR310

site_id	AD3
Number of Residues	1
Details	binding site for residue BR A 312

Chain	Residue
A	GLY154

site_id	AD4
Number of Residues	4
Details	binding site for residue BR A 313

Chain	Residue
A	CYS210
A	ASN211
A	VAL213
A	SER214

site_id	AD5
Number of Residues	4
Details	binding site for residue BR A 314

Chain	Residue
A	SER66
A	SER92
A	BR315
A	HOH727

site_id	AD6
Number of Residues	3
Details	binding site for residue BR A 315

Chain	Residue
A	SER66
A	BR314
A	HOH727

site_id	AD7
Number of Residues	2
Details	binding site for residue BR A 316

Chain	Residue
A	SER195
A	BR325

site_id	AD8
Number of Residues	1
Details	binding site for residue BR A 317

Chain	Residue
A	HIS73

site_id	AD9
Number of Residues	3
Details	binding site for residue BR A 318

Chain	Residue
A	THR107
A	SER108
A	HOH463

site_id	AE1
Number of Residues	5
Details	binding site for residue BR A 319

Chain	Residue
A	SER68
A	LYS69
A	LYS89
A	THR129
A	HOH493

site_id	AE2
Number of Residues	5
Details	binding site for residue BR A 320

Chain	Residue
A	GLN188
A	LYS208
A	VAL209
A	CYS210
A	EDO337

site_id	AE3
Number of Residues	4
Details	binding site for residue BR A 321

Chain	Residue
A	SER78
A	ASN79
A	HOH479
A	HOH523

site_id	AE4
Number of Residues	3
Details	binding site for residue BR A 322

Chain	Residue
A	SER102
A	HOH525
A	HOH722

site_id	AE5
Number of Residues	4
Details	binding site for residue BR A 324

Chain	Residue
A	THR124
A	SER130
A	PRO132
A	HOH750

site_id	AE6
Number of Residues	4
Details	binding site for residue BR A 325

Chain	Residue
A	GLY185
A	BR316
A	HOH412
A	HOH587

site_id	AE7
Number of Residues	2
Details	binding site for residue BR A 326

Chain	Residue
A	GLN115
A	HOH771

site_id	AE8
Number of Residues	2
Details	binding site for residue BR A 327

Chain	Residue
A	VAL58
A	LYS170

site_id	AE9
Number of Residues	2
Details	binding site for residue BR A 328

Chain	Residue
A	GLN199
A	LYS200

site_id	AF1
Number of Residues	3
Details	binding site for residue BR A 329

Chain	Residue
A	ASP145
A	HOH581
A	HOH583

site_id	AF2
Number of Residues	2
Details	binding site for residue BR A 330

Chain	Residue
A	SER95
A	ASN97

site_id	AF3
Number of Residues	4
Details	binding site for residue BR A 331

Chain	Residue
A	ASN97
A	SER98
A	HOH704
A	HOH779

site_id	AF4
Number of Residues	2
Details	binding site for residue BR A 332

Chain	Residue
A	LYS217
A	HOH629

site_id	AF5
Number of Residues	2
Details	binding site for residue BR A 333

Chain	Residue
A	THR6
A	HOH585

site_id	AF6
Number of Residues	7
Details	binding site for residue BEN A 334

Chain	Residue
A	ASP171
A	SER172
A	GLN174
A	GLY196
A	GLY204
A	HOH601
A	HOH739

site_id	AF7
Number of Residues	5
Details	binding site for residue TRS A 335

Chain	Residue
A	SER144
A	SER147
A	HOH436
A	HOH725
A	HOH740

site_id	AF8
Number of Residues	9
Details	binding site for residue EDO A 336

Chain	Residue
A	ARG49
A	ILE55
A	ASN56
A	VAL58
A	HIS73
A	PRO74
A	EDO341
A	HOH475
A	HOH595

site_id	AF9
Number of Residues	7
Details	binding site for residue EDO A 337

Chain	Residue
A	CYS109
A	ALA110
A	PHE161
A	GLN188
A	LYS208
A	BR320
A	HOH515

site_id	AG1
Number of Residues	5
Details	binding site for residue EDO A 338

Chain	Residue
A	GLU62
A	PHE64
A	NA306
A	HOH434
A	HOH632

site_id	AG2
Number of Residues	8
Details	binding site for residue EDO A 339

Chain	Residue
A	ASN79
A	THR80
A	LYS139
A	GLN155
A	TRP193
A	EDO340
A	HOH428
A	HOH449

site_id	AG3
Number of Residues	6
Details	binding site for residue EDO A 340

Chain	Residue
A	TYR5
A	CYS7
A	THR11
A	ASN79
A	EDO339
A	HOH455

site_id	AG4
Number of Residues	11
Details	binding site for residue EDO A 341

Chain	Residue
A	ASN19
A	GLY21
A	TYR22
A	HIS23
A	ILE55
A	ASN56
A	VAL72
A	EDO336
A	HOH402
A	HOH404
A	HOH425

site_id	AG5
Number of Residues	9
Details	binding site for residue EDO A 342

Chain	Residue
A	VAL58
A	ASN77
A	SER78
A	ASN79
A	HOH410
A	HOH424
A	HOH434
A	HOH460
A	HOH484

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
A	VAL36-CYS41

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV

Chain	Residue	Details
A	ASP171-VAL182

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
A	HIS40
A	ASP84
A	SER177

site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING:

Chain	Residue	Details
A	VAL57
A	GLU62
A	ASP171
A	GLN174
A	SER177
A	GLU52
A	ASN54

221051

PDB entries from 2024-06-12

PDB statistics

PDBj update info

Contact PDBj

numon