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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4TNR

Structure basis of cellular dNTP regulation, SAMHD1-GTP-dATP-dATP complex

Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue DTP D 701
ChainResidue
DGLN149
DLYS312
DTYR315
DASP319
DARG366
DHIS370
DTYR374
DGLN375
DHOH803
DHOH804
DHOH805
DLEU150
DARG164
DARG206
DASN207
DHIS210
DHIS215
DHIS233
DASP311
site_idAC2
Number of Residues18
Detailsbinding site for residue GTP D 702
ChainResidue
ALYS116
AVAL117
AILE118
AILE136
AASP137
AGLN142
AARG145
APHE165
AMG701
AHOH801
BLYS523
BDTP701
BHOH801
DTYR155
DVAL156
DVAL378
DARG451
DLYS455
site_idAC3
Number of Residues17
Detailsbinding site for residue DTP D 703
ChainResidue
BVAL156
BPHE157
BARG372
BHIS376
BLYS377
CVAL117
CASN119
CHIS125
CMG702
CGTP703
DARG333
DPHE337
DARG352
DLYS354
DASN358
DLYS523
DHOH806
site_idAC4
Number of Residues4
Detailsbinding site for residue MG D 704
ChainResidue
AGTP703
CDTP704
CHOH802
DLYS116
site_idAC5
Number of Residues15
Detailsbinding site for residue DTP C 701
ChainResidue
CGLN149
CLEU150
CARG164
CARG206
CASN207
CHIS210
CHIS215
CHIS233
CASP311
CLYS312
CTYR315
CASP319
CARG366
CTYR374
CGLN375
site_idAC6
Number of Residues3
Detailsbinding site for residue MG C 702
ChainResidue
CLYS116
CGTP703
DDTP703
site_idAC7
Number of Residues16
Detailsbinding site for residue GTP C 703
ChainResidue
BTYR155
BVAL156
BVAL378
BARG451
BLYS455
CLYS116
CVAL117
CILE118
CILE136
CASP137
CGLN142
CARG145
CPHE165
CMG702
DLYS523
DDTP703
site_idAC8
Number of Residues16
Detailsbinding site for residue DTP C 704
ChainResidue
CARG333
CARG352
CLYS354
CASN358
CLYS523
CHOH802
DVAL117
DASN119
DMG704
AVAL156
APHE157
AARG372
AHIS376
ALYS377
AVAL378
AGTP703
site_idAC9
Number of Residues18
Detailsbinding site for residue DTP B 701
ChainResidue
AVAL117
AILE118
AASN119
AMG701
BARG333
BPHE337
BARG352
BLYS354
BASN358
BLYS523
BHOH801
BHOH802
DVAL156
DPHE157
DARG372
DHIS376
DLYS377
DGTP702
site_idAD1
Number of Residues4
Detailsbinding site for residue MG B 702
ChainResidue
ADTP702
AHOH802
BLYS116
BGTP703
site_idAD2
Number of Residues17
Detailsbinding site for residue GTP B 703
ChainResidue
ALYS523
ADTP702
AHOH802
BLYS116
BVAL117
BILE118
BILE136
BASP137
BGLN142
BARG145
BPHE165
BMG702
CTYR155
CVAL156
CVAL378
CARG451
CLYS455
site_idAD3
Number of Residues14
Detailsbinding site for residue DTP B 704
ChainResidue
BGLN149
BARG164
BARG206
BHIS210
BHIS215
BHIS233
BASP311
BLYS312
BTYR315
BASP319
BARG366
BHIS370
BTYR374
BGLN375
site_idAD4
Number of Residues4
Detailsbinding site for residue MG A 701
ChainResidue
ALYS116
BDTP701
BHOH801
DGTP702
site_idAD5
Number of Residues16
Detailsbinding site for residue DTP A 702
ChainResidue
AARG333
APHE337
AARG352
ALYS354
AASN358
ALYS523
AHOH802
BVAL117
BASN119
BMG702
BGTP703
CVAL156
CPHE157
CARG372
CHIS376
CLYS377
site_idAD6
Number of Residues17
Detailsbinding site for residue GTP A 703
ChainResidue
ATYR155
AVAL156
AVAL378
AARG451
ALYS455
CLYS523
CDTP704
CHOH802
DLYS116
DVAL117
DILE118
DILE136
DASP137
DGLN142
DARG145
DPHE165
DMG704
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"evidences":[{"source":"PubMed","id":"22056990","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues20
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues32
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24141705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BZB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues16
DetailsBinding site: {"description":"in chain C","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"24141705","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues8
DetailsBinding site: {"description":"in chain C","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine; by CDK1","evidences":[{"source":"PubMed","id":"23601106","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26294762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26431200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29610582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29670289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues16
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

251174

PDB entries from 2026-03-25

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