4TMZ

Translation initiation factor eIF5B (517-858) from C. thermophilum, bound to GTPgammaS and potassium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue GSP B 901

Chain	Residue
B	VAL532
B	THR557
B	GLY597
B	ASN648
B	LYS649
B	ASP651
B	ARG652
B	SER716
B	ALA717
B	HIS718
B	MG902
B	ASP533
B	K903
B	HOH1013
B	HOH1014
B	HOH1015
B	THR534
B	GLY535
B	LYS536
B	THR537
B	LYS538
B	GLN549
B	ILE556

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG B 902

Chain	Residue
B	THR537
B	THR557
B	GSP901
B	HOH1013
B	HOH1014

---

site_id	AC3
Number of Residues	5
Details	binding site for residue K B 903

Chain	Residue
B	ASP533
B	GLY555
B	GSP901
B	HOH1016
B	HOH1104

---

site_id	AC4
Number of Residues	5
Details	binding site for residue GOL B 904

Chain	Residue
B	ARG680
B	ASP684
B	GLU702
B	TYR709
B	HOH1001

---

site_id	AC5
Number of Residues	2
Details	binding site for residue CL B 905

Chain	Residue
B	PHE643
B	ARG737

---

site_id	AC6
Number of Residues	2
Details	binding site for residue CL B 906

Chain	Residue
B	ARG803
B	GLU804

---

site_id	AC7
Number of Residues	22
Details	binding site for residue GSP A 901

Chain	Residue
A	VAL532
A	ASP533
A	THR534
A	GLY535
A	LYS536
A	THR537
A	LYS538
A	GLN549
A	ILE556
A	THR557
A	GLY597
A	ASN648
A	LYS649
A	ASP651
A	ARG652
A	SER716
A	ALA717
A	HIS718
A	MG902
A	K903
A	HOH1006
A	HOH1007

---

site_id	AC8
Number of Residues	5
Details	binding site for residue MG A 902

Chain	Residue
A	THR537
A	THR557
A	GSP901
A	HOH1006
A	HOH1007

---

site_id	AC9
Number of Residues	5
Details	binding site for residue K A 903

Chain	Residue
A	ASP533
A	GLY555
A	GSP901
A	HOH1010
A	HOH1052

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	442
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24686316","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TMV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---